The Diversity and Anti-Microbial Activity of Endophytic Actinomycetes Isolated from Medicinal Plants in Panxi Plateau, China

被引：0
作者：
Ke Zhao
Petri Penttinen
Tongwei Guan
Jing Xiao
Qiang Chen
Jun Xu
Kristina Lindström
Lili Zhang
Xiaoping Zhang
Gary A. Strobel
机构：
[1] Sichuan Agricultural University,Department of Microbiology, College of Resource and Environmental Sciences
[2] University of Helsinki,Department of Applied Chemistry and Microbiology
[3] Tarim University,Key Laboratory of Protection and Utilization of Biological Resources in Tarim Basin of Xinjiang Production & Construction Corps
[4] State Oceanic Administration,Key Laboratory of Marine Biogenetic Resources, The Third Institute of Oceanography
[5] Montana State University,Department of Plant Sciences
来源：
Current Microbiology | 2011年 / 62卷
关键词：
Antimicrobial Activity; Medicinal Plant; Indicator Organism; NRPS Gene; Nonribosomal Peptide Synthetase;
D O I：
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中图分类号：
学科分类号：
摘要：
Traditional Chinese medicinal plants are sources of biologically active compounds, providing raw material for pharmaceutical, cosmetic and fragrance industries. The endophytes of medicinal plants participate in biochemical pathways and produce analogous or novel bioactive compounds. Panxi plateau in South-west Sichuan in China with its unique geographical and climatological characteristics is a habitat of a great variety of medicinal plants. In this study, 560 endophytic actinomycetes were isolated from 26 medicinal plant species in Panxi plateau. 60 isolates were selected for 16S rDNA-RFLP analysis and 14 representative strains were chosen for 16S rDNA sequencing. According to the phylogenetic analysis, seven isolates were Streptomyces sp., while the remainder belonged to genera Micromonospora, Oerskovia, Nonomuraea, Promicromonospora and Rhodococcus. Antimicrobial activity analysis combined with the results of amplifying genes coding for polyketide synthetase (PKS-I, PKS-II) and nonribosomal peptide synthetase (NRPS) showed that endophytic actinomycetes isolated from medicinal plants in Panxi plateau had broad-spectrum antimicrobial activity and potential natural product diversity, which further proved that endophytic actinomycetes are valuable reservoirs of novel bioactive compounds.
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页码：182 / 190
页数：8
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