Dopamine D1 Rather than D2 Receptor Agonists Disrupt Prepulse Inhibition of Startle in Mice

被引:0
|
作者
Rebecca J Ralph-Williams
Virginia Lehmann-Masten
Mark A Geyer
机构
[1] Alcohol and Drug Abuse Research Center,Department of Psychiatry
[2] Harvard Medical School and McLean Hospital,undefined
[3] University of California,undefined
来源
Neuropsychopharmacology | 2003年 / 28卷
关键词
dopamine; prepulse inhibition; startle; mice; D1 receptor; D2 receptor;
D O I
暂无
中图分类号
学科分类号
摘要
Although substantial literature describes the modulation of prepulse inhibition (PPI) by dopamine (DA) in rats, few reports address the effects of dopaminergic manipulations on PPI in mice. We characterized the effects of subtype-specific DA agonists in the PPI paradigm to further delineate the specific influences of each DA receptor subtype on sensorimotor gating in mice. The mixed D1/D2 agonist apomorphine and the preferential D1-family agonists SKF82958 and dihydrexidine significantly disrupted PPI, with differing or no effects on startle. In contrast to findings in rats, the D2/D3 agonist quinpirole reduced startle but had no effect on PPI. Pergolide, which has affinity for D2/D3 and D1-like receptors, reduced both startle and PPI, but only at the higher, nonspecific doses. In addition, the D1-family receptor antagonist SCH23390 blocked the PPI-disruptive effects of apomorphine on PPI, but the D2-family receptor antagonist raclopride failed to alter the disruptive effect of apomorphine. These studies reveal potential species differences in the DA receptor modulation of PPI between rats and mice, where D1-family receptors may play a more prominent and independent role in the modulation of PPI in mice than in rats. Nevertheless, due to the limited selectivity of DA receptor agonists, further studies using specific receptor knockout mice are warranted to clarify the respective roles of specific DA receptor subtypes in modulating PPI in mice.
引用
收藏
页码:108 / 118
页数:10
相关论文
共 50 条
  • [21] Ethanol-induced sensitization depends preferentially on D1 rather than D2 dopamine receptors
    Camarini, Rosana
    Marcourakis, Tania
    Teodorov, Elizabeth
    Yonamine, Mauricio
    Calil, Helena Maria
    PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 2011, 98 (02) : 173 - 180
  • [22] Modulation of Postnatal Neurogenesis by Perinatal Asphyxia: Effect of D1 and D2 Dopamine Receptor Agonists
    A. Tapia-Bustos
    R. Perez-Lobos
    V. Vío
    C. Lespay-Rebolledo
    E. Palacios
    A. Chiti-Morales
    D. Bustamante
    M. Herrera-Marschitz
    P. Morales
    Neurotoxicity Research, 2017, 31 : 109 - 121
  • [23] Modulation of Postnatal Neurogenesis by Perinatal Asphyxia: Effect of D1 and D2 Dopamine Receptor Agonists
    Tapia-Bustos, A.
    Perez-Lobos, R.
    Vio, V.
    Lespay-Rebolledo, C.
    Palacios, E.
    Chiti-Morales, A.
    Bustamante, D.
    Herrera-Marschitz, M.
    Morales, P.
    NEUROTOXICITY RESEARCH, 2017, 31 (01) : 109 - 121
  • [24] Synergistic activation of the nitrergic system of the nucleus accumbens by dopamine D1 and D2 receptor agonists
    Saul'Skaya N.B.
    Terekhova E.A.
    Neuroscience and Behavioral Physiology, 2014, 44 (4) : 371 - 375
  • [25] DISCRIMINATIVE STIMULUS PROPERTIES OF D1 AND D2 DOPAMINE AGONISTS IN RATS
    KAMIEN, JB
    GOLDBERG, LI
    WOOLVERTON, WL
    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 1987, 242 (03): : 804 - 811
  • [26] Locomotor behavior of dopamine D1 receptor transgenic/D2 receptor deficient hybrid mice
    Dracheva, S
    Haroutunian, V
    BRAIN RESEARCH, 2001, 905 (1-2) : 142 - 151
  • [27] Genetic variants of dopamine D2 receptor impact heterodimerization with dopamine D1 receptor
    Blasiak, Ewa
    Lukasiewicz, Sylwia
    Szafran-Pilch, Kinga
    Dziedzicka-Wasylewska, Marta
    PHARMACOLOGICAL REPORTS, 2017, 69 (02) : 235 - 241
  • [28] Genetic variants of dopamine D2 receptor impact heterodimerization with dopamine D1 receptor
    Ewa Błasiak
    Sylwia Łukasiewicz
    Kinga Szafran-Pilch
    Marta Dziedzicka-Wasylewska
    Pharmacological Reports, 2017, 69 : 235 - 241
  • [29] Evidence against dopamine D1/D2 receptor heteromers
    Frederick, A. L.
    Yano, H.
    Trifilieff, P.
    Vishwasrao, H. D.
    Biezonski, D.
    Meszaros, J.
    Urizar, E.
    Sibley, D. R.
    Kellendonk, C.
    Sonntag, K. C.
    Graham, D. L.
    Colbran, R. J.
    Stanwood, G. D.
    Javitch, J. A.
    MOLECULAR PSYCHIATRY, 2015, 20 (11) : 1373 - 1385
  • [30] Dopamine D1–D2 receptor heterodimers: A literature review
    Vekshina N.L.
    Anokhin P.K.
    Veretinskaya A.G.
    Shamakina I.Y.
    Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry, 2017, 11 (2) : 111 - 119