SLE - Complex cytokine effects in a complex autoimmune disease: tumor necrosis factor in systemic lupus erythematosus

被引：0
作者：
Martin Aringer
Josef S Smolen
机构：
[1] University of Vienna,Department of Rheumatology, Internal Medicine III
来源：
Arthritis Res Ther | / 5卷
关键词：
autoantibodies; cytokines; immune regulation; inflammation; SLE;
D O I：
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摘要：
Tumor necrosis factor (TNF) is a proinflammatory cytokine and a B-cell growth factor. It has numerous possible effects on T lymphocytes and dendritic cells, and it influences apoptosis. These differential effects may in part explain why patients under TNF-blocker therapy can develop autoantibodies to nuclear antigens, and may shed some light on the finding that low TNF fosters autoimmune disease in some mouse strains. On the contrary, TNF is increased in the blood and in the inflamed kidneys of systemic lupus erythematosus patients. Several studies in lupus-prone mice other than the F1 generation of New Zealand Black mice crossed with New Zealand White mice suggest that TNF is highly proinflammatory in the efferent limb and is potentially detrimental in lupus organ disease. Therefore, TNF blockade probably constitutes an efficacious therapeutic option.
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  • [21] Hofler E(2001)Membrane-bound TNF supports secondary lymphoid organ structure but is subservient to secreted TNF in driving autoimmune inflammation Immunity 15 533-S152
  • [22] Hiesberger H(2001)The molecular basis of lymphoid architecture and B cell responses: implications for immunodeficiency and immunopathology Curr Mol Med 1 689-791
  • [23] Smolen JS(2002)Multiple roles for tumor necrosis factor-alpha and lymphotoxin alpha/beta in immunity and autoimmunity Arthritis Res 4 S141-7011
  • [24] Graninger WB(1987)Effect of tumor necrosis factor alpha on mitogen-activated human B cells J Exp Med 166 786-132
  • [25] Aringer M(1994)Tumor necrosis factor alpha is an autocrine growth factor for normal human B cells Proc Natl Acad Sci USA 91 7007-1480
  • [26] Feierl E(1997)Tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) in B-lymphocyte function Methods 11 128-3164
  • [27] Steiner G(1995)Interaction between CD40 and its ligand gp39 in the development of murine lupus nephritis J Immunol 154 1470-221
  • [28] Stummvoll GH(1996)Anti-CD40 ligand antibody treatment prevents the development of lupus-like nephritis in a subset of New Zealand black × New Zealand white mice. Response correlates with the absence of an anti-antibody response J Immunol 157 3159-170
  • [29] Höfler E(2001)Monoclonal antibodies and other biologic therapies Lupus 10 216-232
  • [30] Steiner CW(2001)The treatment of lupus with cyclosporin A Lupus 10 165-1195
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