Mouse models of high-risk neuroblastoma

被引:0
作者
Alvin Kamili
Caroline Atkinson
Toby N. Trahair
Jamie I. Fletcher
机构
[1] UNSW Sydney,Children’s Cancer Institute Australia, Lowy Cancer Research Centre
[2] UNSW Sydney,School of Women’s and Children’s Health
[3] Sydney Children’s Hospital,Kids Cancer Centre
来源
Cancer and Metastasis Reviews | 2020年 / 39卷
关键词
Neuroblastoma; GEMM; PDX; Mouse model; Pre-clinical testing;
D O I
暂无
中图分类号
学科分类号
摘要
Informative and realistic mouse models of high-risk neuroblastoma are central to understanding mechanisms of tumour initiation, progression, and metastasis. They also play vital roles in validating tumour drivers and drug targets, as platforms for assessment of new therapies and in the generation of drug sensitivity data that can inform treatment decisions for individual patients. This review will describe genetically engineered mouse models of specific subsets of high-risk neuroblastoma, the development of patient-derived xenograft models that more broadly represent the diversity and heterogeneity of the disease, and models of primary and metastatic disease. We discuss the research applications, advantages, and limitations of each model type, the importance of model repositories and data standards for supporting reproducible, high-quality research, and potential future directions for neuroblastoma mouse models.
引用
收藏
页码:261 / 274
页数:13
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