Comparative Analysis of Superoxide Dismutase Activity between Acute Pharmacological Models and a Transgenic Mouse Model of Huntington's Disease

被引：0
作者：
Abel Santamaría
Francisca Pérez-Severiano
Erika Rodríguez-Martínez
Perla D. Maldonado
José Pedraza-Chaverri
Camilo Ríos
José Segovia
机构：
[1] Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez,Departamento de Neuroquímica
[2] SSA,Departamento de Fisiología, Biofisica y Neurociencias
[3] Centro de Investigación y de Estudios Avanzados del IPN,Facultad de Química
[4] Universidad Nacional Autónoma de México,undefined
来源：
Neurochemical Research | 2001年 / 26卷
关键词：
Striatum; oxidative damage; free radicals; excitotoxins; transgenic; Huntington's disease; superoxide dismutase;
D O I：
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学科分类号：
摘要：
We examined the activity of striatal superoxide dismutase (SOD) in two acute pharmacological models of Huntington's disease (HD), and compared it with SOD activity in the striata of mice transgenic for the HD mutation. Total SOD, and Cu/ZnSOD activities increased in young transgenic mice, but decreased in older (35 week) mice. We consider that the increased enzyme activity represents a compensatory mechanism to protect cells from free radical-induced damage, but the system becomes insufficient in older animals. Major decreases in SOD activity were also observed both after quinolinic acid and 3-nitropropionic acid intrastriatal injections. The present results indicate that in both types of HD models striatal oxidative damage occurs, and that it is associated with alterations in the cellular antioxidant system.
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页码：419 / 424
页数：5
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