Prognostic and therapeutic potential of senescent stromal fibroblasts in prostate cancer

被引：0
作者：
Joakin O. Mori
Isra Elhussin
W. Nathaniel Brennen
Mindy K. Graham
Tamara L. Lotan
Clayton C. Yates
Angelo M. De Marzo
Samuel R. Denmeade
Srinivasan Yegnasubramanian
William G. Nelson
Gerald V. Denis
Elizabeth A. Platz
Alan K. Meeker
Christopher M. Heaphy
机构：
[1] Boston University Chobanian & Avedisian School of Medicine and Boston Medical Center,Department of Medicine
[2] Johns Hopkins University School of Medicine,Department of Oncology, Sidney Kimmel Comprehensive Cancer Center
[3] Johns Hopkins University School of Medicine,Department of Urology and the James Buchanan Brady Urological Institute
[4] Johns Hopkins University School of Medicine,Department of Pathology
[5] Johns Hopkins University School of Medicine,Department of Radiation Oncology and Molecular Radiation Sciences
[6] Boston University Chobanian & Avedisian School of Medicine,Department of Pharmacology and Experimental Therapeutics
[7] Johns Hopkins Bloomberg School of Public Health,Department of Epidemiology
[8] Boston University Chobanian & Avedisian School of Medicine,Department of Pathology and Laboratory Medicine
来源：
Nature Reviews Urology | 2024年 / 21卷
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摘要：
The stromal component of the tumour microenvironment in primary and metastatic prostate cancer can influence and promote disease progression. Within the prostatic stroma, fibroblasts are one of the most prevalent cell types associated with precancerous and cancerous lesions; they have a vital role in the structural composition, organization and integrity of the extracellular matrix. Fibroblasts within the tumour microenvironment can undergo cellular senescence, which is a stable arrest of cell growth and a phenomenon that is emerging as a recognized hallmark of cancer. Supporting the idea that cellular senescence has a pro-tumorigenic role, a subset of senescent cells exhibits a senescence-associated secretory phenotype (SASP), which, along with increased inflammation, can promote prostate cancer cell growth and survival. These cellular characteristics make targeting senescent cells and/or modulating SASP attractive as a potential preventive or therapeutic option for prostate cancer.
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页码：258 / 273
页数：15
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