Activity of Doxorubicin Covalently Bound to a Novel Human Serum Albumin Microcapsule

被引：0
作者：
Martin Eatock
Nicola Church
Roy Harris
Wilson Angerson
Colin McArdle
Ray French
Chris Twelves
机构：
[1] Glasgow Royal Infirmary NHS Trust,Department of Medical Oncology
[2] Andaris Limited,CRC Department of Medical Oncology
[3] University Department of Surgery,undefined
[4] Glasgow Royal Infirmary NHS Trust,undefined
[5] University of Glasgow,undefined
来源：
Investigational New Drugs | 1999年 / 17卷
关键词：
doxorubicin; albumin microcapsule; endocytosis; cytotoxicity; flow cytometry;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Doxorubicin is widely used in the treatment of human malignancies, however is associated with significant cardiac, bone marrow and gastro-intestinal toxicity. Delivery systems may ameliorate this toxicity and increase treatment specificity by increasing the proportion of drug delivered to sites of disease. We have developed a novel preparation of doxorubicin (Dox) covalently linked to a heat stabilised human serum albumin microparticle (HSAM) carrier (median particle diameter of 4 μm) and assessed its activity in 4 malignant cell lines.
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页码：111 / 120
页数：9
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