Interspecies differences in clinical characteristics and risk factors for third-generation cephalosporin resistance between Escherichia coli and Klebsiella pneumoniae bloodstream infection in patients with liver cirrhosis

被引：0

作者：

Sin Young Ham

Hyungul Jung

Kyoung-Ho Song

Hyeonju Jeong

Jongtak Jung

Song Mi Moon

Jeong Su Park

Nak-Hyun Kim

Eun Sun Jang

Jin-Wook Kim

Sook-Hyang Jeong

Eu Suk Kim

Hong Bin Kim

机构：

[1] Seoul National University Bundang Hospital,Division of Infectious Diseases, Department of Internal Medicine

[2] Korea Veterans Hospital,Department of Internal Medicine

[3] Seoul National University College of Medicine,Department of Internal Medicine

[4] Seoul National University Bundang Hospital,Department of Laboratory Medicine

来源：

European Journal of Clinical Microbiology & Infectious Diseases | 2022年 / 41卷

关键词：

Third-generation cephalosporin resistance; Interspecies difference; Bloodstream infection; Liver cirrhosis; Mortality; Enterobacteriaceae;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

This retrospective study aimed to clarify the interspecies differences in the clinical characteristics and risk factors of bloodstream infection (BSI) due to third-generation cephalosporin-resistant (3GC-R) Escherichia coli (EC) and Klebsiella pneumoniae (KP) in patients with liver cirrhosis (LC). KP BSI had more comorbidities and higher treatment failure rate than EC BSI. Non-alcoholic LC was a risk factor for treatment failure in EC, whereas it was not associated with KP. Risk factors for BSI due to 3GC-R strain were nosocomial infection in EC, and β-lactam/fluoroquinolone treatment ≤ 30 days in KP. These results could help predict outcomes of BSI and improve clinical practice.

引用

页码：1459 / 1465

页数：6