Interspecies differences in clinical characteristics and risk factors for third-generation cephalosporin resistance between Escherichia coli and Klebsiella pneumoniae bloodstream infection in patients with liver cirrhosis

被引：0
作者：
Sin Young Ham
Hyungul Jung
Kyoung-Ho Song
Hyeonju Jeong
Jongtak Jung
Song Mi Moon
Jeong Su Park
Nak-Hyun Kim
Eun Sun Jang
Jin-Wook Kim
Sook-Hyang Jeong
Eu Suk Kim
Hong Bin Kim
机构：
[1] Seoul National University Bundang Hospital,Division of Infectious Diseases, Department of Internal Medicine
[2] Korea Veterans Hospital,Department of Internal Medicine
[3] Seoul National University College of Medicine,Department of Internal Medicine
[4] Seoul National University Bundang Hospital,Department of Laboratory Medicine
来源：
European Journal of Clinical Microbiology & Infectious Diseases | 2022年 / 41卷
关键词：
Third-generation cephalosporin resistance; Interspecies difference; Bloodstream infection; Liver cirrhosis; Mortality; Enterobacteriaceae;
D O I：
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学科分类号：
摘要：
This retrospective study aimed to clarify the interspecies differences in the clinical characteristics and risk factors of bloodstream infection (BSI) due to third-generation cephalosporin-resistant (3GC-R) Escherichia coli (EC) and Klebsiella pneumoniae (KP) in patients with liver cirrhosis (LC). KP BSI had more comorbidities and higher treatment failure rate than EC BSI. Non-alcoholic LC was a risk factor for treatment failure in EC, whereas it was not associated with KP. Risk factors for BSI due to 3GC-R strain were nosocomial infection in EC, and β-lactam/fluoroquinolone treatment ≤ 30 days in KP. These results could help predict outcomes of BSI and improve clinical practice.
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页码：1459 / 1465
页数：6
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