The Airway Colonization by Opportunistic Filamentous Fungi in Patients with Cystic Fibrosis: Recent Updates

被引：7
作者：
Touati K. [1 ]
Nguyen D.N.L. [2 ]
Delhaes L. [1 ,2 ]
机构：
[1] Department of Parasitology-Mycology, Lille Hospital, Lille 2 University, Boulevard du Pr J. Leclercq, Lille Cedex
[2] Biology and Diversity of Emerging Eukaryotic Pathogens, Pasteur Institute of Lille, Center for Infection and Immunity of Lille (CIIL), University of Lille-Nord de France, Inserm U1019, CNRS UMR 8204, EA4547, 1 rue du Professeur Calmette, BP 245, Lille Cede
来源：
Current Fungal Infection Reports | 2014年 / 8卷 / 4期
关键词：
Airway colonization; Aspergillus; Cystic fibrosis; Exophiala; Filamentous fungi; Fungal diagnosis; Lung microbiome; Mould; Mycobiota; Opportunistic fungus; Opportunistic infection; Respiratory infections; Scedosporium;
D O I：
10.1007/s12281-014-0197-7
中图分类号：
学科分类号：
摘要：
There has been a remarkable increase recently in the isolation of fungi such as Aspergillus fumigatus, species of the Pseudallescheria boydii/Scedosporium apiospermum complex, and Exophiala sp. from the respiratory tract of patients with cystic fibrosis (CF). This review describes the recent insights into the epidemiology, ecology, and physiopathology of the filamentous fungi able to colonize and/or to infect the airways of CF patients, and that may be responsible for accelerated lung function decline. We summarize salient features not only on highly prevalent species such as Aspergillus and Scedosporium, but also on more recently described fungi such as Rasamsonia argillacea. In addition, we discuss the challenges inherent in tracking and interpreting rates of fungal colonization/infection in the CF patient population, taking into consideration the polymicrobial composition of the CF lung environment, the corresponding cross-kingdom interactions, and the new concept of mycobiota. Further research is warranted to clarify the role of fungi in CF lung disease and its therapeutic management. © 2014, Springer Science+Business Media New York.
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页码：302 / 311
页数：9
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