Increased Expression of Plasma and CD4+ T Lymphocyte Costimulatory Molecule CD26 in Adult Patients with Allergic Asthma

被引：0
作者：
Samantha W. M. Lun
C. K. Wong
Fanny W. S. Ko
David S. C. Hui
Christopher W. K. Lam
机构：
[1] The Chinese University of Hong Kong,Department of Chemical Pathology
[2] Prince of Wales Hospital,Department of Medicine and Therapeutics
[3] The Chinese University of Hong Kong,Department of Chemical Pathology
[4] Prince of Wales Hospital,undefined
[5] The Chinese University of Hong Kong,undefined
[6] Prince of Wales Hospital,undefined
来源：
Journal of Clinical Immunology | 2007年 / 27卷
关键词：
allergy; asthma; costimulatory molecules; CD26; T lymphocytes;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
CD26, which is a costimulatory molecule and peptidase, is responsible for the degradation of interferon (IFN)-γ-induced chemokines. To elucidate the immunopathological role of CD26 in allergic asthma, we investigated plasma soluble CD26 (sCD26) concentration and its cell surface expression on lymphocytes, monocytes, CD4+ T helper, CD8+ T suppressor plus cytotoxic T, invariant natural killer T (iNKT), and CD19+ B lymphocytes in allergic asthmatic patients. Plasma sCD26 was significantly elevated in asthmatic patients regardless of inhaled corticosteroid treatment (all P < 0.05). Cell surface expression of CD26 was significantly up-regulated on lymphocytes, especially on CD4+ and iNKT lymphocytes (all P < 0.05), but not on other cell types. Significant positive correlations were found between sCD26 and the percentage of eosinophils, Th2-related chemokines CCL5 and CCL22, and costimulatory molecule sCTLA-4 (all P < 0.05). In conclusion, the aberrant expression of CD26 may contribute to the inflammatory process and Th2 predominance in the immunopathogenesis of allergic asthma.
引用
收藏
页码：430 / 437
页数：7
相关论文
共 82 条
  • [1] Yssel H(2000)Characterization of T cell subpopulations involved in the pathogenesis of asthma and allergic diseases Int Arch Allergy Immunol 121 10-8
  • [2] Groux H(2003)The role of T lymphocytes in the pathogenesis of asthma J Allergy Clin Immunol 111 450-63
  • [3] Larche M(1998)Expression of aminopeptidase N and dipeptidyl peptidase IV in the healthy and asthmatic bronchus Clin Exp Allergy 28 110-20
  • [4] Robinson DS(2001)Amino-terminal truncation of CXCR3 agonists impairs receptor signaling and lymphocyte chemotaxis, while preserving antiangiogenic properties Blood 98 3554-61
  • [5] Kay AB(2003)I. Dipeptidyl-peptidase IV from bench to bedside: an update on structural properties, functions, and clinical aspects of the enzyme DPP IV Crit Rev Clin Lab Sci 40 209-94
  • [6] Van DVV(1993)Dipeptidyl peptidase IV (CD26) and aminopeptidase N (CD13) catalyzed hydrolysis of cytokines and peptides with N-terminal cytokine sequences FEBS 336 61-4
  • [7] Wierenga-Wolf AF(1998)The chemokine receptors CXCR3 and CCR5 mark subsets of T cells associated with certain inflammatory reactions J Clin Invest 101 746-54
  • [8] Driaansen-Soeting PW(2006)Circulating levels of soluble CD26 are associated with phobic anxiety in women Prog Neuropsychopharmacol Biol Psychiatry 30 1334-6
  • [9] Proost P(2006)Coexpression and interaction of CXCL10 and CD26 in mesenchymal cells by synergising inflammatory cytokines: CXCL8 and CXCL10 are discriminative markers for autoimmune arthropathies Arthritis Res Ther 8 R107-60
  • [10] Schutyser E(1997)Inhibitors of dipeptidyl peptidase IV induce secretion of transforming growth factor-beta 1 in PWM-stimulated PBMC and T cells Immunology 91 354-55
123456789