Clinical, Diagnostic and Prognostic Characteristics of Primary Cutaneous Gamma Delta T-cell Lymphomas

被引：10
作者：
Muhsen I.N. [1 ]
El Fakih R. [2 ]
Hamadani M. [3 ]
Lazarus H.M. [4 ]
Kharfan-Dabaja M.A. [5 ]
Aljurf M. [2 ]
机构：
[1] Department of Medicine, Houston Methodist Hospital, Houston, TX
[2] Oncology Center, King Faisal Specialist Hospital and Research Center, PO Box 3354, Riyadh
[3] BMT and Cellular Therapy Program, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI
[4] Division of Hematology and Oncology, Case Western Reserve University, Cleveland, OH
[5] Division of Hematology-Oncology and Blood and Marrow Transplantation and Cellular Therapies Program, Mayo Clinic, Jacksonville, FL
来源：
Clinical Hematology International | 2022年 / 4卷 / 1-2期
关键词：
Cutaneous lymphomas; Gamma-delta; T-cell lymphoma;
D O I：
10.1007/s44228-022-00011-9
中图分类号：
学科分类号：
摘要：
Primary cutaneous γδ T-cell lymphoma (PCGDTL) is a rare subtype of non-Hodgkin lymphoma (NHL) that arises from T-cells with γδ T-cell receptors. The exact incidence of PCGDTL is unknown, as it is usually lumped with other cutaneous lymphomas, which are also uncommon. It is one of the peripheral T-cell lymphoma (PTCL) subtypes which is known to have a dismal prognosis due to poor response and the paucity of available therapies. Despite the rarity and uncertainties of PCGDTL, a number of studies over the past decade were published about the pathologic, diagnostic, cytogenetic and clinical features of this disease. These diagnostic advances will open the doors to explore new therapeutics for this rare entity, specifically targeted and immune therapies. In this review, we highlight these advances, summarize the contemporary treatment approaches, and shed the light on future potential therapeutic targets. © 2022, The Author(s).
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页码：1 / 10
页数：9
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