An APOBEC cytidine deaminase mutagenesis pattern is widespread in human cancers

被引：0

作者：

Steven A Roberts

Michael S Lawrence

Leszek J Klimczak

Sara A Grimm

David Fargo

Petar Stojanov

Adam Kiezun

Gregory V Kryukov

Scott L Carter

Gordon Saksena

Shawn Harris

Ruchir R Shah

Michael A Resnick

Gad Getz

Dmitry A Gordenin

机构：

[1] Laboratory of Molecular Genetics,Department of Pathology

[2] National Institute of Environmental Health Sciences,undefined

[3] The Broad Institute of MIT and Harvard,undefined

[4] Integrative Bioinformatics,undefined

[5] National Institute of Environmental Health Sciences,undefined

[6] Harvard Medical School,undefined

[7] SRA International,undefined

[8] Inc.,undefined

[9] Massachusetts General Hospital Cancer Center,undefined

[10] Massachusetts General Hospital,undefined

来源：

Nature Genetics | 2013年 / 45卷

关键词：

D O I：

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中图分类号：

学科分类号：

摘要：

Dmitry Gordenin, Gad Getz and colleagues report an analysis of mutation patterns in cancer genomes and find evidence of mutagenesis induced by APOBEC cytidine deaminase enzymes. They find an APOBEC mutagenesis pattern in bladder, cervical, breast, head and neck, and lung cancers, representing 68% of all mutations in some samples.

引用

页码：970 / 976

页数：6

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