Interaction Mechanism Between Indoxyl Sulfate, a Typical Uremic Toxin Bound to Site II, and Ligands Bound to Site I of Human Serum Albumin

被引:0
作者
Toshiaki Sakai
Keishi Yamasaki
Tomoko Sako
Ulrich Kragh-Hansen
Ayaka Suenaga
Masaki Otagiri
机构
[1] Kumamoto University,Faculty of Pharmaceutical Sciences
[2] University of Aarhus,Department of Medical Biochemistry
来源
Pharmaceutical Research | 2001年 / 18卷
关键词
human serum albumin; indoxyl sulfate; dansyl-L-asparagine; high-affinity binding site; allosteric interaction; N to B transition;
D O I
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中图分类号
学科分类号
摘要
Purpose. The study was performed for clarifying the mechanism of interaction between indoxyl sulfate (IS), a typical uremic toxin bound to site II, and site I-ligands when bound to human serum albumin (HSA). The effect of the N to B transition on the interactions was also examined.
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页码:520 / 524
页数:4
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