Interaction Mechanism Between Indoxyl Sulfate, a Typical Uremic Toxin Bound to Site II, and Ligands Bound to Site I of Human Serum Albumin

被引：0
作者：
Toshiaki Sakai
Keishi Yamasaki
Tomoko Sako
Ulrich Kragh-Hansen
Ayaka Suenaga
Masaki Otagiri
机构：
[1] Kumamoto University,Faculty of Pharmaceutical Sciences
[2] University of Aarhus,Department of Medical Biochemistry
来源：
Pharmaceutical Research | 2001年 / 18卷
关键词：
human serum albumin; indoxyl sulfate; dansyl-L-asparagine; high-affinity binding site; allosteric interaction; N to B transition;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Purpose. The study was performed for clarifying the mechanism of interaction between indoxyl sulfate (IS), a typical uremic toxin bound to site II, and site I-ligands when bound to human serum albumin (HSA). The effect of the N to B transition on the interactions was also examined.
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页码：520 / 524
页数：4
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