The GPCR Network: a large-scale collaboration to determine human GPCR structure and function

被引：0

作者：

Raymond C. Stevens

Vadim Cherezov

Vsevolod Katritch

Ruben Abagyan

Peter Kuhn

Hugh Rosen

Kurt Wüthrich

机构：

[1] Raymond C. Stevens,Vadim Cherezov and Vsevolod Katritch are at the Department of Molecular Biology

[2] The Scripps Research Institute,Peter Kuhn is at the Department of Cell Biology

[3] 10550 North Torrey Pines Road,Hugh Rosen is at the Department of Chemical Physiology and at the The Scripps Research Institute Molecular Screening Center

[4] La Jolla,Kurt Wüthrich is at the Department of Molecular Biology and at the Skaggs Institute of Chemical Biology

[5] California 92037,undefined

[6] USA.,undefined

[7] Ruben Abagyan is at the University of California San Diego (UCSD) Skaggs School of Pharmacy and Pharmaceutical Sciences and at the San Diego Supercomputer Center,undefined

[8] La Jolla,undefined

[9] California 92093,undefined

[10] USA.,undefined

[11] The Scripps Research Institute,undefined

[12] 10550 North Torrey Pines Road,undefined

[13] La Jolla,undefined

[14] California 92037,undefined

[15] USA.,undefined

[16] The Scripps Research Institute,undefined

[17] 10550 North Torrey Pines Road,undefined

[18] La Jolla,undefined

[19] California 92037,undefined

[20] USA.,undefined

[21] The Scripps Research Institute,undefined

[22] 10550 North Torrey Pines Road,undefined

[23] La Jolla,undefined

[24] California 92037,undefined

[25] USA.,undefined

来源：

Nature Reviews Drug Discovery | 2013年 / 12卷

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摘要：

The GPCR Network was established in 2010 with the aim of structurally characterizing 15–25 representative human G protein-coupled receptors (GPCRs) within 5 years; so far, more than eight have been determined. Here, Stevens and colleagues provide an overview of this collaborative effort and the challenges remaining in gaining detailed insights into the structure–function relationships of this receptor superfamily.

引用

页码：25 / 34

页数：9