Post-translational modifications in tumor-associated carbonic anhydrases

被引：0
作者：
Anna Di Fiore
Claudiu T. Supuran
Andrea Scaloni
Giuseppina De Simone
机构：
[1] Istituto di Biostrutture e Bioimmagini-CNR,NEUROFARBA Department, Pharmaceutical and Nutraceutical Section
[2] University of Firenze,Proteomics and Mass Spectrometry Laboratory, ISPAAM
[3] National Research Council,undefined
来源：
Amino Acids | 2022年 / 54卷
关键词：
Carbonic anhydrase IX; Carbonic anhydrase XII; Post-translational modifications ; Drug design;
D O I：
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中图分类号：
学科分类号：
摘要：
Human carbonic anhydrases IX (hCA IX) and XII (hCA XII) are two proteins associated with tumor formation and development. These enzymes have been largely investigated both from a biochemical and a functional point of view. However, limited data are currently available on the characterization of their post-translational modifications (PTMs) and the functional implication of these structural changes in the tumor environment. In this review, we summarize existing literature data on PTMs of hCA IX and hCA XII, such as disulphide bond formation, phosphorylation, O-/N-linked glycosylation, acetylation and ubiquitination, highlighting, when possible, their specific role in cancer pathological processes.
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页码：543 / 558
页数：15
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