Increased α-Tubulin1b Expression Indicates Poor Prognosis and Resistance to Chemotherapy in Hepatocellular Carcinoma

被引:0
作者
Cuihua Lu
Jing Zhang
Song He
Chunhua Wan
Aidong Shan
Yingying Wang
Litao Yu
Guoliang Liu
Ken Chen
Jing Shi
Yixin Zhang
Runzhou Ni
机构
[1] Affiliated Hospital of Nantong University,Department of Gastroenterology
[2] Nantong University Cancer Hospital,Department of Pathology
来源
Digestive Diseases and Sciences | 2013年 / 58卷
关键词
Hepatocellular carcinoma; α-Tubulin1b (TUBA1B); Ki-67; Prognosis; Chemotherapy;
D O I
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学科分类号
摘要
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页码:2713 / 2720
页数:7
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[1]  
Jemal A(2005)Cancer statistics, 2005 CA Cancer J Clin 55 10-30
[2]  
Murray T(2011)Ibulocydine is a novel prodrug cdk inhibitor that effectively induces apoptosis in hepatocellular carcinoma cells J Biol Chem 286 19662-19671
[3]  
Ward E(1997)Treatment of hepatocellular carcinoma: a systematic review of randomized controlled trials Ann Oncol 8 117-136
[4]  
Cho SJ(2002)Transarterial chemoembolization for unresectable hepatocellular carcinoma: meta-analysis of randomized controlled trials1 Radiology 224 47-54
[5]  
Kim YJ(2010)Structure-based virtual screening of novel tubulin inhibitors and their characterization as anti-mitotic agents Bioorgan Med Chem 18 7092-7100
[6]  
Surh YJ(2008)Moscatilin induces apoptosis in human colorectal cancer cells: a crucial role of c-jun nh2-terminal protein kinase activation caused by tubulin depolymerization and DNA damage Clin Cancer Res 14 4250-4258
[7]  
Kim BM(2009)The 3 ms of central spindle assembly: microtubules, motors and maps Nat Rev Mol Cell Biol 10 9-20
[8]  
Lee SK(2010)Cancer cells acquire mitotic drug resistance properties through beta i-tubulin mutations and alterations in the expression of beta-tubulin isotypes PLoS ONE 5 e12564-1246
[9]  
Simonetti RG(2010)Tubulin binding cofactor c (tbcc) suppresses tumor growth and enhances chemosensitivity in human breast cancer cells BMC Cancer 10 135-398
[10]  
Liberati A(2011)Specific beta-tubulin isotypes can functionally enhance or diminish epothilone b sensitivity in non-small cell lung cancer cells PLoS ONE 6 e21717-605