Outcomes of platelet transfusion in patients with thrombotic thrombocytopenic purpura: a retrospective case series study

被引:0
作者
Amy Zhou
Rohtesh S. Mehta
Roy E. Smith
机构
[1] Washington University in St. Louis,Department of Hematology and Medical Oncology
[2] University of Pittsburgh Medical Center,Department of Hematology and Medical Oncology
来源
Annals of Hematology | 2015年 / 94卷
关键词
Thrombotic thrombocytopenic purpura; Platelet transfusion; Thrombocytopenia;
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摘要
Current guidelines advise against the transfusion of platelets in patients with thrombotic thrombocytopenic purpura (TTP) except in cases of life-threatening hemorrhage. We conducted a retrospective medical chart review to examine the outcomes of patients with TTP who received platelet transfusion at our institution from September 2002 to September 2012. A search for “thrombotic thrombocytopenic purpura” in the discharge summary identified 233 patients, out of which only 15 patients had TTP and received platelet transfusion. Primary outcomes were death due to any cause, myocardial infarction, ischemic stroke, coma, seizure, or worsening neurologic status within 24 h of platelet transfusion. Secondary outcomes included bleeding and worsening thrombocytopenia. No adverse outcomes occurred within 24 h of platelet transfusion. Two patients experienced bleeding following renal biopsy despite having platelet counts of greater than 50,000/μl and receiving one pack of pooled platelets prior to the procedures. The response to transfusion was variable. In general, platelet transfusion was not detrimental in this population; however, the efficacy is uncertain.
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页码:467 / 472
页数:5
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