Treatment of advanced mycosis fungoides by allogeneic stem-cell transplantation with a nonmyeloablative regimen

被引：0
|
作者：
D Soligo
A Ibatici
E Berti
P Morandi
E Longhi
L Venegoni
M Corbellino
C Annaloro
L Robbiolo
A Della Volpe
E Alessi
G Lambertenghi Deliliers
机构：
[1] IRCCS Ospedale Maggiore,Department of Hematology
[2] IRCCS Ospedale Maggiore,Department of Dermatology
[3] Transplantation Immunology and Blood Transfusion Services,undefined
[4] IRCCS Ospedale Maggiore,undefined
[5] Institute of Infectious and Tropical Diseases,undefined
[6] University of Milano,undefined
来源：
Bone Marrow Transplantation | 2003年 / 31卷
关键词：
mycosis fungoides; nonmyeloablative regimen; allogeneic stem cell transplantation;
D O I：
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学科分类号：
摘要：
Given the poor prognosis of patients with advanced cutaneous T-cell lymphoma and the high transplant-related mortality associated with conventional allogeneic bone marrow transplantation, we performed nonmyeloablative transplantation of allogeneic stem cells (ASCT) from HLA-identical siblings in three patients with this disease. All patients achieved full donor engraftment, clearance of clonal T cells leading to durable complete remissions but experienced high incidence of infections, which proved fatal in one case. These results suggest that nonmyeloablative ASCT is a novel and potentially curative therapy for patients with advanced T-cell lymphomas who have a histocompatible sibling.
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页码：663 / 666
页数：3
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