Anti-cancer activity of quercetin in neuroblastoma: an in vitro approach

被引：0
作者：
E. Sugantha Priya
K. Selvakumar
S. Bavithra
P. Elumalai
R. Arunkumar
P. Raja Singh
A. Brindha Mercy
J. Arunakaran
机构：
[1] University of Madras,Department of Endocrinology, Dr. ALM. Post Graduate Institute of Basic Medical Sciences
来源：
Neurological Sciences | 2014年 / 35卷
关键词：
Neuroblastoma; Neuro2a cell line; Quercetin; Apoptosis;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Neuroblastoma is a neuroendocrine tumour derived from neural crest cells and it remains a major therapeutic challenge in pediatric oncology. As response rates to chemotherapy are low, surgery remains the only effective treatment but since many tumors have metastasized at the time of diagnosis, curative surgery is rarely achieved. Consequently, a substantial need for new therapeutic options emerges. Quercetin a flavonoid, has been reported to lower the risk of several cancers. This study was designed to investigate its effects on apoptosis induction in the N2a, a mouse neuroblastoma cell line. The cell viability was determined by dimethyl thiazolyl tetrazolium bromide assay and diamidino-2-phenylindole staining was performed to confirm the apoptosis. The gene expression of bcl-w, p53, p27 and protein expression of caspases (3 and 9), bax, cytochrome-c were studied. This in vitro outcome suggests that quercetin can be used as a potent anti-cancer drug in future.
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页码：163 / 170
页数：7
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