Ferroptosis As a Mechanism for Health Effects of Essential Trace Elements and Potentially Toxic Trace Elements

被引：0
作者：
Yuyan Xu
Ruobi Chen
Qibing Zeng
机构：
[1] Guizhou Medical University,The Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education & School of Public Helath
来源：
Biological Trace Element Research | 2023年 / 201卷
关键词：
Ferroptosis; Essential trace elements; Potentially toxic trace elements; Mechanism; Health;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Ferroptosis is a unique form of programmed cell death driven by iron-dependent phospholipid peroxidation that was proposed in recent years. It plays an important role in processes of various trace element-related diseases and is regulated by redox homeostasis and various cellular metabolic pathways (iron, amino acids, lipids, sugars), as well as disease-related signaling pathways. Some limited pioneering studies have demonstrated ferroptosis as a mechanism for the health effects of essential trace elements and potentially toxic trace elements, with crosstalk among them. The aim of this review is to bring together research articles and identify key direct and indirect evidence regarding essential trace elements (iron, selenium, zinc, copper, chromium, manganese) and potentially toxic trace elements (arsenic, aluminum, mercury) and their possible roles in ferroptosis. Our review may help determine future research priorities and opportunities.
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页码：4262 / 4274
页数：12
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