Interactions between GB virus type C and HIV

被引：24
作者：
Sarah L. George
Sabina Wünschmann
James McCoy
Jinhua Xiang
Jack T. Stapleton
机构：
[1] UIHC,Internal Medicine
来源：
Current Infectious Disease Reports | 2002年 / 4卷 / 6期
关键词：
Human Immunodeficiency Virus; Human Immunodeficiency Virus Infection; Human Immunodeficiency Virus Replication; Human Immunodeficiency Virus Viral Load; Human Immunodeficiency Virus Disease Progression;
D O I：
10.1007/s11908-002-0044-9
中图分类号：
学科分类号：
摘要：
GB virus C (GBV-C, also known as hepatitis G virus) commonly causes human infection. Genetically, it is closely related to hepatitis C virus, but GBV-C appears to grow primarily in lymphocytes, not hepatocytes. Although it causes persistent infection in about 25% to 50% of infected individuals, numerous studies have failed to connect GBV-C with any disease process. GBV-C is transmitted sexually, parenterally, and vertically, and due to these shared modes of transmission, coinfection is common among HIV-infected individuals. Of 10 studies done of HIV-GBV-C coinfection, eight found a beneficial effect of GBV-C viremia on HIVrelated mortality or response to therapy. The mechanism by which GBV-C may improve survival of HIV-positive people is not known; however, in vitro studies suggest that GBV-C inhibits HIV replication, and preliminary data also point toward alterations in cytokine and/or chemokine expression by GBV-C-infected cells.
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页码：550 / 558
页数：8
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