A randomized, double-blind, phase 2b study to investigate the efficacy, safety, tolerability and pharmacokinetics of a single-dose regimen of ferroquine with artefenomel in adults and children with uncomplicated Plasmodium falciparum malaria

被引：0
作者：
Yeka Adoke
Rella Zoleko-Manego
Serge Ouoba
Alfred B. Tiono
Grace Kaguthi
Juvêncio Eduardo Bonzela
Tran Thanh Duong
Alain Nahum
Marielle Bouyou-Akotet
Bernhards Ogutu
Alphonse Ouedraogo
Fiona Macintyre
Andreas Jessel
Bart Laurijssens
Mohammed H. Cherkaoui-Rbati
Cathy Cantalloube
Anne Claire Marrast
Raphaël Bejuit
David White
Timothy N. C. Wells
Florian Wartha
Didier Leroy
Afizi Kibuuka
Ghyslain Mombo-Ngoma
Daouda Ouattara
Irène Mugenya
Bui Quang Phuc
Francis Bohissou
Denise P. Mawili-Mboumba
Fredrick Olewe
Issiaka Soulama
Halidou Tinto
机构：
[1] Infectious Diseases Research Collaboration (IDRC),Department of Tropical Medicine, Bernhard Nocht Institute for Tropical Medicine & I. Dep. of Medicine
[2] Centre de Recherches Médicales de Lambaréné (CERMEL),Unité de Recherche Clinique de Nanoro
[3] University Medical Centre Hamburg-Eppendorf,Unité de Recherche Clinique de Banfora, C/H Régional de Banfora
[4] Institut de Recherche en Sciences de La Santé,Département de Parasitologie
[5] Centre National de Recherche Et de Formation Sur Le Paludisme (CNRFP),Mycologie
[6] Kenya Medical Research Institute-Centre for Respiratory Diseases Research (KEMRI-CRDR),Médecine Tropicale, Faculté de Médecine Et Des Sciences de La Santé
[7] Chokwe Health Research and Training Centre,Unité de Recherche Clinique de Niangoloko, S/C Centre Medical de Niangoloko
[8] National Institute of Malariology,Institute for Tropical Medicine
[9] Parasitology and Entomology,undefined
[10] Centre de Recherche Entomologique de Cotonou (CREC) and Hôpital La Croix de Zinvié,undefined
[11] Université Des Sciences de La Santé,undefined
[12] Kenya Medical Research Institute,undefined
[13] Centre National de Recherche Et de Formation Sur Le Paludisme (CNRFP),undefined
[14] Medicines for Malaria Venture (MMV),undefined
[15] Sanofi Research and Development,undefined
[16] BEL Pharm Consulting,undefined
[17] Sanofi Research and Development,undefined
[18] IQVIA CEVA,undefined
[19] University of Tübingen,undefined
来源：
Malaria Journal | / 20卷
关键词：
Ferroquine; Combination treatment; Pharmacokinetics/pharmacodynamics; Exposure–response; C580Y; mutation; Resistance; Parasite clearance; Vomiting;
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