Bioreactors for engineering patient-specific tissue grafts

被引：21

作者：

Sarkar, Naboneeta ^{[1
,2
]}

Bhumiratana, Sarindr ^{[3
]}

Geris, Liesbet ^{[4
]}

Papantoniou, Ioannis ^{[4
,5
]}

Grayson, Warren L. ^{[1
,2
,6
,7
,8
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Biomed Engn, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Sch Med, Translat Tissue Engn Ctr, Baltimore, MD 21218 USA

[3] EpiBone Inc, Brooklyn, NY USA

[4] Katholieke Univ Leuven, Prometheus Div Skeletal Tissue Engn, Leuven, Belgium

[5] Katholieke Univ Leuven, Skeletal Biol & Engn Res Ctr, Dept Dev & Regenerat, Leuven, Belgium

[6] Johns Hopkins Univ, Dept Mat Sci & Engn, Baltimore, MD 21218 USA

[7] Johns Hopkins Univ, Dept Chem & Biomol Engn, Baltimore, MD 21218 USA

[8] Johns Hopkins Univ, Inst Nanobiotechnol, Baltimore, MD 21218 USA

来源：

NATURE REVIEWS BIOENGINEERING | 2023年 / 1卷 / 05期

关键词：

ROTATOR CUFF REPAIR; STEM-CELLS; MECHANICAL-PROPERTIES; BLOOD-VESSELS; NEOTISSUE GROWTH; CLINICAL-TRIAL; CONTRAST AGENT; CYCLIC STRAIN; TENDON REPAIR; PERFUSION;

D O I：

10.1038/s44222-023-00036-6

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Bioreactors have the potential to advance the clinical application of cell-based therapies. Cell expansion bioreactors have been used commercially for therapeutic applications; however, bioreactor-based engineering of 3D tissue grafts remains challenging owing to the complexity of tissue architectures, cellular heterogeneity and the lack of non-invasive, tissue-specific biomarkers with which to assess graft viability and maturation. Consequently, only a few bioreactor-based start-up companies that engineer patient-specific tissue grafts have emerged. In this Review, we discuss patient-specific bioreactors that can be used to engineer skin, small-diameter arteries and musculoskeletal tissues. We evaluate the impact of precision manufacturing, including 3D bioprinting, automation and non-invasive sensing, on optimizing the biological, chemical and physical parameters of the bioreactors that are required for specific tissue regeneration. We discuss the commercially available tissue-engineering bioreactors and the potential of digital twins and automation, and we outline the scientific and regulatory pathways that must be followed to enable the translation of tissue-specificbioreactors to the clinic.

引用

页码：361 / 377

页数：17

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