The Role of C/EBPβ in Mammary Gland Development and Breast Cancer

被引：0
作者：
Sandra L. Grimm
Jeffrey M. Rosen
机构：
[1] Baylor College of Medicine,Department of Molecular and Cellular Biology
来源：
Journal of Mammary Gland Biology and Neoplasia | 2003年 / 8卷
关键词：
CCAAT/enhancer binding protein; mammary gland; cell lineage; knockout mice; epithelial cells;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The CCAAT/enhancer binding protein (C/EBP) family of bZIP transcription factors control the proliferation and differentiation of a variety of tissues. While C/EBPα and -∂ are also expressed in the mammary gland, the multiple protein isoforms of C/EBPβ appear to play a critical role in mammary gland development and breast cancer. Targeted deletion of all the C/EBPβ isoforms results in a severe inhibition of lobuloalveolar development and a block to functional differentiation, as well as more subtle changes in ductal morphogenesis. The altered expression of a number of molecular markers, including the progesterone, estrogen, and prolactin receptors, the transporter proteins (NKCC1 and aquaporin 5), and several markers of skin differentiation (Sprr2A and keratin 6), suggests that germline deletion of C/EBPβ results in an altered cell fate. Thus, C/EBPβ appears to play a role in the specification of progenitor cell fate not only in the mammary gland, but also in a number of other tissues.
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页码：191 / 204
页数：13
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