Alpha-Tryptase as a Risk-Modifying Factor for Mast Cell–Mediated Reactions

[1] Schwartz LB(1987)Tryptase levels as an indicator of mast-cell activation in systemic anaphylaxis and mastocytosis N Engl J Med 316 1622-1626

[2] Metcalfe DD(2006)Tryptase genetics and anaphylaxis J Aller Clin Immunol 117 1411-1414

[3] Miller JS(1998)Human beta-tryptase is a ring-like tetramer with active sites facing a central pore Nature 392 306-311

[4] Earl H(2019)Impact of naturally forming human alpha/beta-tryptase heterotetramers in the pathogenesis of hereditary alpha-tryptasemia J Exp Med 216 2348-2361

[5] Sullivan T(2016)Non-IgE mediated mast cell activation Eur J Pharmacol 778 33-43

[6] Caughey GH(2015)Mast cell: a multi-functional master cell Front Immunol 6 620-2710

[7] Pereira PJ(1995)The alpha form of human tryptase is the predominant type present in blood at baseline in normal subjects and is elevated in those with systemic mastocytosis J Clin Invest 96 2702-5673

[8] Bergner A(2003)Tryptase precursors are preferentially and spontaneously released, whereas mature tryptase is retained by HMC-1 cells, Mono-Mac-6 cells, and human skin-derived mast cells J Immunol 170 5667-271

[9] Macedo-Ribeiro S(2007)Tryptase haplotype in mastocytosis: relationship to disease variant and diagnostic utility of total tryptase levels Clin Immunol 123 268-208

[10] Huber R(2019)Serum baseline tryptase level as a marker for the severity of anaphylaxis Int Arch Aller Immunol 179 201-606

[1] Schwartz LB(1987)Tryptase levels as an indicator of mast-cell activation in systemic anaphylaxis and mastocytosis N Engl J Med 316 1622-1626

[2] Metcalfe DD(2006)Tryptase genetics and anaphylaxis J Aller Clin Immunol 117 1411-1414

[3] Miller JS(1998)Human beta-tryptase is a ring-like tetramer with active sites facing a central pore Nature 392 306-311

[4] Earl H(2019)Impact of naturally forming human alpha/beta-tryptase heterotetramers in the pathogenesis of hereditary alpha-tryptasemia J Exp Med 216 2348-2361

[5] Sullivan T(2016)Non-IgE mediated mast cell activation Eur J Pharmacol 778 33-43

[6] Caughey GH(2015)Mast cell: a multi-functional master cell Front Immunol 6 620-2710

[7] Pereira PJ(1995)The alpha form of human tryptase is the predominant type present in blood at baseline in normal subjects and is elevated in those with systemic mastocytosis J Clin Invest 96 2702-5673

[8] Bergner A(2003)Tryptase precursors are preferentially and spontaneously released, whereas mature tryptase is retained by HMC-1 cells, Mono-Mac-6 cells, and human skin-derived mast cells J Immunol 170 5667-271

[9] Macedo-Ribeiro S(2007)Tryptase haplotype in mastocytosis: relationship to disease variant and diagnostic utility of total tryptase levels Clin Immunol 123 268-208

[10] Huber R(2019)Serum baseline tryptase level as a marker for the severity of anaphylaxis Int Arch Aller Immunol 179 201-606