Role of Adenosine Receptors in Neuroprotective Effect during Global Cerebral Ischemia

被引：0
|
作者：
V. I. Kulinsky
L. N. Minakina
L. A. Usov
机构：
[1] Irkutsk Medical University,Department of Biochemistry, Department of Pharmacology
来源：
Bulletin of Experimental Biology and Medicine | 2001年 / 131卷
关键词：
adenosine receptors; neuroprotectors; cerebral ischemia;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Selective A1 adenosine receptor agonists produced a considerable neuroprotective effect during global cerebral ischemia. The neuroprotective effect decreased in the order: A1 agonists-NECA-adenosine-A2A agonist CGS 21680, while selective A3 adenosine receptor agonist was ineffective. Inhibitory analysis showed that A1 adenosine receptors mediate the neuroprotective effect of CPA, are involved in the effects of NECA and adenosine (but not CGS 21680), and participate in natural resistance to cerebral ischemia. The role of A2B adenosine receptors in the realization of neuroprotective effects was also demonstrated.
引用
收藏
页码：454 / 456
页数：2
相关论文
共 50 条
  • [21] Is chlormethiazole neuroprotective in experimental global cerebral ischemia? A microdialysis and behavioral study
    Thaminy, S
    Reymann, JM
    Heresbach, N
    Allain, H
    Lechat, P
    BentueFerrer, D
    PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1997, 56 (04) : 737 - 745
  • [22] Neuroprotective Effects of Carbonic Anhydrase Inhibition and Cyclic Adenosine Monophosphate Activation in Mouse Model of Transient Global Cerebral Ischemia and Reperfusion
    Manish Kumar
    Komalpreet Kaur
    Thakur Gurjeet Singh
    NeuroMolecular Medicine, 2023, 25 : 217 - 229
  • [23] Neuroprotective Effects of Carbonic Anhydrase Inhibition and Cyclic Adenosine Monophosphate Activation in Mouse Model of Transient Global Cerebral Ischemia and Reperfusion
    Kumar, Manish
    Kaur, Komalpreet
    Singh, Thakur Gurjeet
    NEUROMOLECULAR MEDICINE, 2023, 25 (02) : 217 - 229
  • [24] Additivity and independence of neuroprotective effects of GABAA and GABAB receptor agonists in complete global cerebral ischemia
    V. I. Kulinskii
    G. V. Mikhel’son
    Bulletin of Experimental Biology and Medicine, 2000, 130 : 772 - 774
  • [25] Additivity and independence of neuroprotective effects of GABAA and GABAB receptor agonists in complete global cerebral ischemia
    Kulinskii, VI
    Mikhel'son, GV
    BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2000, 130 (08) : 772 - 774
  • [26] Neuroprotective effect of 8-OH-DPAT in global cerebral ischemia assessed by stereological cell counting
    Torup, L
    Moller, A
    Sager, TN
    Diemer, NH
    EUROPEAN JOURNAL OF PHARMACOLOGY, 2000, 395 (02) : 137 - 141
  • [27] PROTECTIVE EFFECT OF INTRACEREBROVENTRICULAR INJECTION OF ADENOSINE AGONISTS DURING TOTAL CEREBRAL-ISCHEMIA
    KULINSKII, VI
    USOV, LA
    SUFIANOVA, GZ
    SUFIANOV, AA
    BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 1994, 117 (06) : 626 - 628
  • [28] Neuroprotective effect of diazoxide on brain injury induced by cerebral ischemia/reperfusion during deep hypothermia
    He, Xiaomin
    Mo, Xuming
    Gu, Haitao
    Chen, Feng
    Gu, Qun
    Peng, Wei
    Qi, Jirong
    Shen, Li
    Sun, Jian
    Zhang, Rufang
    Yin, K. J.
    JOURNAL OF THE NEUROLOGICAL SCIENCES, 2008, 268 (1-2) : 18 - 27
  • [29] Neuroprotective effect of ethanol and Modafinil on focal cerebral ischemia in rats
    Abbasi, Yusef
    Shabani, Ronak
    Mousavizadeh, Kazem
    Soleimani, Mansoureh
    Mehdizadeh, Mehdi
    METABOLIC BRAIN DISEASE, 2019, 34 (03) : 805 - 819
  • [30] Neuroprotective effect of ethanol and Modafinil on focal cerebral ischemia in rats
    Yusef Abbasi
    Ronak Shabani
    Kazem Mousavizadeh
    Mansoureh Soleimani
    Mehdi Mehdizadeh
    Metabolic Brain Disease, 2019, 34 : 805 - 819
12345