Role of Adenosine Receptors in Neuroprotective Effect during Global Cerebral Ischemia

Selective A1 adenosine receptor agonists produced a considerable neuroprotective effect during global cerebral ischemia. The neuroprotective effect decreased in the order: A1 agonists-NECA-adenosine-A2A agonist CGS 21680, while selective A3 adenosine receptor agonist was ineffective. Inhibitory analysis showed that A1 adenosine receptors mediate the neuroprotective effect of CPA, are involved in the effects of NECA and adenosine (but not CGS 21680), and participate in natural resistance to cerebral ischemia. The role of A2B adenosine receptors in the realization of neuroprotective effects was also demonstrated.