Role of Orphan Nuclear Receptors in the Regulation of Drug-Metabolising Enzymes

被引：0
作者：
Hongbing Wang
Edward L. LeCluyse
机构：
[1] University of North Carolina at Chapel Hill,Division of Drug Delivery & Disposition, School of Pharmacy
来源：
Clinical Pharmacokinetics | 2003年 / 42卷
关键词：
Glucocorticoid Receptor; Nuclear Receptor; Constitutive Androstane Receptor; Orphan Nuclear Receptor; Constitutive Androstane Receptor Activation;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
During the past several years, important advances have been made in our understanding of the mechanisms that regulate the expression of genes that determine drug clearance, including phase I and phase II drug-metabolising enzymes and drug transporters. Orphan nuclear receptors have been recognised as key mediators of drug-induced changes in both metabolism and efflux mechanisms.
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页码：1331 / 1357
页数：26
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