Distribution and Time-Course of 4-Hydroxynonenal, Heat Shock Protein 110/105 Family Members and Cyclooxygenase-2 Expression in the Hippocampus of Rat During Trimethyltin-Induced Neurodegeneration

被引：0
作者：
V. Corvino
E. Marchese
N. Zarkovic
K. Zarkovic
M. Cindric
G. Waeg
F. Michetti
M. C. Geloso
机构：
[1] Università Cattolica del Sacro Cuore,Institute of Anatomy and Cell Biology
[2] Laboratory for Oxidative Stress,Division of Molecular Medicine
[3] Rudjer Boskovic Institute,Department of Pathology, Neuropathology Unit
[4] University of Zagreb School of Medicine,Institute of Molecular Biosciences
[5] University Hospital Center,undefined
[6] Karl Franzens University of Graz,undefined
来源：
Neurochemical Research | 2011年 / 36卷
关键词：
Neurodegeneration; 4-hydroxynonenal; Heat shock proteins; COX-2; Trimethyltin; Lipid peroxidation;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Trimethyltin (TMT), an organotin compound considered a useful tool to obtain an experimental model of neurodegeneration, exhibits neurotoxicant effects selectively localised in the limbic system and especially in the hippocampus, which are different in the rat and in mice. In the rat hippocampus, we investigated the expression of aldehyde 4-hydroxynonenal, a major bioactive marker of membrane lipid peroxidation, heat shock protein (HSP) 110/105 family members, markers of oxidative stress, and the neuroinflammatory marker cyclooxygenase-2 after TMT-intoxication at various time points after treatment. Our data show that TMT-induced neurodegeneration in the rat hippocampus is associated specifically with oxidative stress and lipid peroxidation, but not with HSP expression, indicating species-specific differences in the neurotoxicity of TMT between rats and mice.
引用
收藏
页码：1490 / 1500
页数：10
相关论文
共 155 条
  • [1] Coyle JT(1993)Oxidative stress, glutamate and neurodegenerative disorders Science 262 689-695
  • [2] Puttfarken P(1999)4-Hydroxynonenal as a second messenger of free radicals and growth modifying factor Life Sci 65 1901-1904
  • [3] Zarkovic N(2003)4-hydroxynonenal as a bioactive marker of pathopysiological processes Mol Asp Med 24 281-291
  • [4] Zarkovic K(2003)S100B protein and 4-hydroxynonenal in the spinal cord of wobbler mice Neurochem Res 28 341-345
  • [5] Schaur RJ(2003)4-hydroxynonenal and neurodegenerative diseases Mol Asp Med 24 293-303
  • [6] Zarkovic N(2009)Induction of heat shock proteins for protection against oxidative stress Adv Drug Deliv Rev 28 310-318
  • [7] Corvino V(1989)Toxicity of dibutyltin, tributyltin and other organotin compounds to humans and to experimental animals Toxicology 55 253-298
  • [8] Businaro R(1990)The neurotoxicology and pathology of organomercury, organolead, and organotin J Toxicol Sci Suppl 4 125-151
  • [9] Geloso MC(1978)Trimethyltin poisoning. Report of two cases Int Arch Occup Environ Health 41 1-6
  • [10] Zarkovic K(1992)Trimethyltin poisoning: report of a case with postmortem examination Clin Neuropathol 11 256-259
12345678910