Hit-to-lead optimization of amino-carboxamide benzothiazoles as LSD1 inhibitors

被引:0
|
作者
Du’a Al bustanji
Soraya Alnabulsi
Enas A. Al-Hurani
机构
[1] Jordan University of Science and Technology,Department of Medicinal Chemistry and Pharmacognosy, Faculty of Pharmacy
[2] P.O. Box 3030,undefined
来源
关键词
LSD1 enzyme; hit-to-lead optimization; anticancer; structure-activity relationship; amino-carboxamide benzothiazoles.;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
页码:910 / 929
页数:19
相关论文
共 50 条
  • [1] Hit-to-lead optimization of amino-carboxamide benzothiazoles as LSD1 inhibitors
    Al Bustanji, Du'a
    Alnabulsi, Soraya
    Al-Hurani, Enas A. A.
    MEDICINAL CHEMISTRY RESEARCH, 2023, 32 (05) : 910 - 929
  • [2] Amino-carboxamide benzothiazoles as potential LSD1 hit inhibitors. Part I: Computational fragment-based drug design
    Alnabulsi, Soraya
    Al-Hurani, Enas A.
    Al-Shar'i, Nizar A.
    El-Elimat, Tamam
    JOURNAL OF MOLECULAR GRAPHICS & MODELLING, 2019, 93
  • [3] Hit-to-lead optimization of aminohydantoins as b-Secretase inhibitors
    Nowak, Pawel
    Aulabaugh, Ann
    Chen, Joan
    Cole, Derek C.
    Chopra, Rajiv
    Cowling, Rebecca
    Dar, Marilyn
    Ellingboe, John W.
    Fan, Kristi Y.
    Hu, Baihua
    Jacobsen, Steve
    Jani, Minakshi
    Jin, Guixan
    Lo, Mei-Chu
    Malamas, Michael S.
    Manas, Eric S.
    Narasimhan, Rani
    Robichaud, Albert
    Sabus, Chantel
    Stock, Joseph R.
    Tischler, Mark
    Turner, Jim
    Wagner, Erik
    Zhou, Ping
    Bard, Jonathan
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2007, 233 : 818 - 818
  • [4] Substituted 2-arylbenzothiazoles as kinase inhibitors: Hit-to-lead optimization
    Tasler, Stefan
    Mueller, Oliver
    Wieber, Tanja
    Herz, Thomas
    Pegoraro, Stefano
    Saeb, Wael
    Lang, Martin
    Krauss, Rolf
    Totzke, Frank
    Zirrgiebel, Ute
    Ehlert, Jan E.
    Kubbutat, Michael H. G.
    Schaechtele, Christoph
    BIOORGANIC & MEDICINAL CHEMISTRY, 2009, 17 (18) : 6728 - 6737
  • [5] Enhancing the hit-to-lead properties of lead optimization libraries
    Pickett, SD
    McLay, IM
    Clark, DE
    JOURNAL OF CHEMICAL INFORMATION AND COMPUTER SCIENCES, 2000, 40 (02): : 263 - 272
  • [6] Novel Triazeneindole Antibiotics: Synthesis and Hit-to-Lead Optimization
    Sorokin, Boris
    Filimonova, Alla
    Emelianova, Anna
    Kublitski, Vadim
    Gvozd, Artem
    Shmygarev, Vladimir
    Yampolsky, Ilia
    Guglya, Elena
    Gusev, Evgeniy
    Kuzmin, Denis
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2025, 26 (05)
  • [7] Discovery of reversible LSD1 inhibitors
    Kanouni, Toufike
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2017, 254
  • [8] Discovery of potent dipeptidyl peptidase IV inhibitors through pharmacophore hybridization and hit-to-lead optimization
    Zeng, Shaogao
    Xie, Hui
    Zeng, Li-li
    Lu, Xin
    Zhao, Xin
    Zhang, Gui-cheng
    Tu, Zheng-chao
    Xu, Hong-jiang
    Yang, Ling
    Zhang, Xi-quan
    Hu, Wenhui
    BIOORGANIC & MEDICINAL CHEMISTRY, 2013, 21 (07) : 1749 - 1755
  • [9] MEDI 291-Structure-guided optimization of bacterial ATPase inhibitors: From hit-to-lead
    Kohnen, Amanda L.
    Bensen, Daniel C.
    Creighton, Christopher J.
    Cunningham, Mark L.
    Tari, Leslie W.
    Trzoss, Michael
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2008, 236
  • [10] Hit-to-lead optimization on aryloxybenzamide derivative virtual screening hit against SIRT
    Yagci, Semih
    Gozelle, Mahmut
    Kaya, Selen Gozde
    Ozkan, Yesim
    Aksel, Ahmet Bugra
    Bakar-Ates, Filiz
    Dundar, Yasemin
    Eren, Gokcen
    BIOORGANIC & MEDICINAL CHEMISTRY, 2021, 30