HMGB1 in Hormone-Related Cancer: a Potential Therapeutic Target

被引：0
作者：
Madhuwanti Srinivasan
Souresh Banerjee
Allison Palmer
Guoxing Zheng
Aoshuang Chen
Maarten C. Bosland
André Kajdacsy-Balla
Ramaswamy Kalyanasundaram
Gnanasekar Munirathinam
机构：
[1] University of Illinois,Department of Biomedical Sciences
[2] College of Medicine,Department of Pathology
[3] University of Illinois at Chicago,undefined
[4] University of Illinois Cancer Center,undefined
来源：
Hormones and Cancer | 2014年 / 5卷
关键词：
Ethyl Pyruvate; Clear Cell Renal Cell Carcinoma; Glycyrrhetinic Acid; Cervical Squamous Cell Carcinoma; HMGB1 Level;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
High-mobility group box 1 (HMGB1) is a dynamic nuclear protein participating in transcription, chromatin remodelling, and DNA recombination and repair processes. Accumulating evidence indicates that its function now extends beyond the nucleus, notably its extracellular role in inflammation. HMGB1 is implicated as a late mediator of sepsis and is also believed to promote atherosclerosis and other inflammatory diseases such as rheumatoid arthritis and systemic lupus erythematosus. Interestingly, deregulation of HMGB1 is shown to be associated with the hallmarks of cancer development. Moreover, several clinical studies have shown that HMGB1 is a promising biomarker for a variety of cancer types. In this review, we provide novel insights into the role and mechanisms of HMGB1, in particular, to hormone-related cancers and its potential to serve as a therapeutic target.
引用
收藏
页码：127 / 139
页数：12
相关论文
共 746 条
[1]  
Walker JM(1977)A comparison of the amino-terminal sequences of two calf-thymus chromatin non-histone proteins Int J Pept Protein Res 9 220-223
[2]  
Goodwin GH(2001)Thermodynamics of HMGB1 interaction with duplex DNA Biochemistry 40 10254-10261
[3]  
Johns EW(2003)Retroposed copies of the HMG genes: a window to genome dynamics Genome Res 13 800-812
[4]  
Wietzes P(2005)GR and HMGB1 interact only within chromatin and influence each other’s residence time Mol Cell 18 109-121
[5]  
Gaastra W(1998)High-mobility group chromatin proteins 1 and 2 functionally interact with steroid hormone receptors to enhance their DNA binding in vitro and transcriptional activity in mammalian cells Mol Cell Biol 18 4471-4487
[6]  
Muller S(1996)HMG1 interacts with HOX proteins and enhances their DNA binding and transcriptional activation EMBO J 15 4981-4991
[7]  
Bianchi ME(2002)HMGB1 and HMGB2 cell-specifically down-regulate the p53- and p73-dependent sequence-specific transactivation from the human Bax gene promoter J Biol Chem 277 7157-7164
[8]  
Knapp S(2003)HMGB1 interacts differentially with members of the Rel family of transcription factors Biochem Biophys Res Commun 302 421-426
[9]  
Strichman-Almashanu LZ(2013)p53-dependent release of Alarmin HMGB1 is a central mediator of senescent phenotypes J Cell Biol 201 613-629
[10]  
Bustin M(2005)C-Myc-independent restoration of multiple phenotypes by two C-Myc target genes with overlapping functions Cancer Res 65 2097-2107
12345678910