Synthesis, thermal, spectral, antimicrobial and cytotoxicity profile of the Schiff bases bearing pyrazolone moiety and their Cu(II) complexes

被引：0
作者：
Irina Zarafu
Rodica Olar
Mariana Carmen Chifiriuc
Coralia Bleotu
Petre Ioniţă
Mihaela Mulţescu
Gabriela Ioniţă
Graţiela Grădişteanu
Arnaud Tatibouët
Mihaela Badea
机构：
[1] University of Bucharest,Department of Organic Chemistry, Faculty of Chemistry
[2] University of Bucharest,Department of Inorganic Chemistry, Faculty of Chemistry
[3] University of Bucharest,Department of Microbiology, Faculty of Biology
[4] ICUB,The Research Institute of the University of Bucharest
[5] Stefan S Nicolau Institute of Virology,ICOA
[6] Romanian Academy,UMR7311, CNRS
[7] “Ilie Murgulescu” Physical Chemistry Institute,undefined
[8] University of Orleans,undefined
来源：
Journal of Thermal Analysis and Calorimetry | 2018年 / 134卷
关键词：
4-Aminoantipyrine; Copper complex; Biofilm; Cytotoxicity; Schiff base; Thermal behaviour;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A series of Schiff bases resulted in the [1 + 1] condensation of 8-alkyl-2-hydroxy-tricyclo[7.3.1.02.7]-tridecan-13-one with the 4-amino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one, and their complexes CuL(CH3COO)2·nH2O were synthesized. The compounds were characterized by microanalytical, ESI–MS, NMR, IR, electronic and EPR spectra. Based on the ESI–MS and IR spectra, a mononuclear structure with both Schiff base and acetate as chelate was proposed for complexes. An elongated rhombic stereochemistry was assigned considering electronic and EPR data. The thermal analyses have evidenced processes as water elimination, acetate decomposition as well as oxidative degradation of the Schiff base moiety. The bioevaluation of compounds in relation to planktonic and biofilm-embedded microbial cells, as well as to human cells, indicates an improved activity of complexes over ligands. The same tendency was observed for antioxidant activity.
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页码：1851 / 1861
页数：10
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