Synthesis and evaluation of in vitro antimicrobial activity of novel 2-[2-(aroyl)aroyloxy]methyl-1,3,4-oxadiazoles

被引：0

作者：

V. Girish

Noor Fatima Khanum

H. D. Gurupadaswamy

Shaukath Ara Khanum

机构：

[1] University of Mysore,Department of Chemistry

[2] Maharani’s Science College,Department of Food Science and Nutrition

来源：

Russian Journal of Bioorganic Chemistry | 2014年 / 40卷

关键词：

benzophenones; 1,3,4-oxadiazoles; antimicrobial activity; MIC;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Synthetic pathway of the ten novel 2-[2-(aroyl)aroyloxy]methyl-1,3,4-oxadiazoles as new potential antimicrobial agents is illustrated. Intramolecular cyclization of 2-(2-aroylaryloxy) aceto hydrazides to 2-[2-(aroyl)aroyloxy]methyl-1,3,4-oxadiazoles was achieved with triethyl orthoformate in good yields. The compounds were characterized by IR, 1H NMR, mass spectra and by means of CHN analysis. The target compounds were tested for their in vitro antimicrobial activity against representative strains by disc diffusion method and micro dilution methods. Several compounds showed antimicrobial activity comparable with or higher than the standard drugs.

引用

页码：330 / 335

页数：5

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