Synthesis and evaluation of in vitro antimicrobial activity of novel 2-[2-(aroyl)aroyloxy]methyl-1,3,4-oxadiazoles

被引：0
|
作者：
V. Girish
Noor Fatima Khanum
H. D. Gurupadaswamy
Shaukath Ara Khanum
机构：
[1] University of Mysore,Department of Chemistry
[2] Maharani’s Science College,Department of Food Science and Nutrition
来源：
Russian Journal of Bioorganic Chemistry | 2014年 / 40卷
关键词：
benzophenones; 1,3,4-oxadiazoles; antimicrobial activity; MIC;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Synthetic pathway of the ten novel 2-[2-(aroyl)aroyloxy]methyl-1,3,4-oxadiazoles as new potential antimicrobial agents is illustrated. Intramolecular cyclization of 2-(2-aroylaryloxy) aceto hydrazides to 2-[2-(aroyl)aroyloxy]methyl-1,3,4-oxadiazoles was achieved with triethyl orthoformate in good yields. The compounds were characterized by IR, 1H NMR, mass spectra and by means of CHN analysis. The target compounds were tested for their in vitro antimicrobial activity against representative strains by disc diffusion method and micro dilution methods. Several compounds showed antimicrobial activity comparable with or higher than the standard drugs.
引用
收藏
页码：330 / 335
页数：5
相关论文
共 50 条
  • [31] Synthesis of Some Novel 2-[2-(aroyl-aroxy)-methyl]-4-phenyl-1,3-thiazoles as Potent Anti-Inflammatory Agents
    Rai, Neithnadka Premsai
    Venu, T. D.
    Manuprasad, B. K.
    Shashikanth, Sheena
    Arunachalam, P. N.
    Firdouse, Aiysha
    CHEMICAL BIOLOGY & DRUG DESIGN, 2010, 75 (04) : 400 - 406
  • [32] Synthesis, antimicrobial activity, and in silico studies of 1,2,4-oxadiazoles from ethyl levulinate
    da Cunha Lima, Josefa Aqueline
    Santos Costa, Erick Caique
    Bezerra, Giselle Barbosa
    Silva, Jadson de Farias
    Alves Caina, Rodrigo Ribeiro
    de Freitas Filho, Joao Rufino
    Rufino Freitas, Juliano Carlo
    ACTA BRASILIENSIS, 2020, 4 (03): : 161 - 167
  • [33] Synthesis & Characterization of 2-(substituted-phenyl)acetohydrazide Analogs, 1,3,4-oxadiazoles, and 1,2,4-triazine Ring Systems: A Novel Class of Potential Analgesic and Anti-Inflammatory Agents
    Nayak, Prakash S.
    Narayana, Badiadka
    Fernandes, Jennifer
    Sarojini, Balladka K.
    Sheik, Sana
    Shashidhara, Kenkere S.
    Chandrashekhar, Konambi R.
    Byrappa, Kullaiah
    LETTERS IN DRUG DESIGN & DISCOVERY, 2016, 13 (06) : 547 - 562
  • [34] SYNTHESIS, ANTIMICROBIAL EVALUATION AND IN SILICO STUDIES OF THE (E)-3-(ARYL)-5-STYRYL-1,2,4-OXADIAZOLES
    da Cunha Lima, Josefa Aqueline
    Santos Costa, Erick Caique
    Bezerra, Giselle Barbosa
    Silva, Jadson de Farias
    Alves Caiana, Rodrigo Ribeiro
    De Freitas Filho, Joao Rufino
    Rufino Freitas, Juliano Carlo
    BIOSCIENCE JOURNAL, 2022, 38
  • [35] Synthesis and Antimicrobial Activity of 1-(5-Mercapto-1,3,4-Oxadiazol-2-yl)-2-(Pyridine-2-ylamino)ethanone
    Salimon, Jumat
    Salih, Nadia
    Hussien, Hasan
    SAINS MALAYSIANA, 2011, 40 (05): : 445 - 450
  • [36] Synthesis and antimicrobial activity of some novel 2-(substituted fluorobenzoylimino)-3-(substituted fluorophenyl)-4-methyl-1,3-thiazolines
    Saeed, Aamer
    Shaheen, Uzma
    Hameed, Abdul
    Kazmi, Faiza
    JOURNAL OF FLUORINE CHEMISTRY, 2010, 131 (03) : 333 - 339
  • [37] Synthesis and Antimicrobial Activity of New 5-(2-Thienyl)-1,2,4-triazoles and 5-(2-Thienyl)-1,3,4-oxadiazoles and Related Derivatives
    Al-Omar, Mohamed A.
    MOLECULES, 2010, 15 (01) : 502 - 514
  • [38] Synthesis and antimicrobial activity of some new 2-(3′-phenoxy phenyl)-3-aryl-5-methyl-4-thiazolidinones
    Solankee, A
    Patel, J
    Kapadia, K
    Thakor, I
    Upadhyay, K
    ASIAN JOURNAL OF CHEMISTRY, 2002, 14 (02) : 718 - 722
  • [39] Synthesis and biological evaluation of some new 2,5-disubstituted 1,3,4-oxadiazoles from 3-(arylsulfonyl) propanehydrazides
    Kumar, L. Vinay
    Naik, P. Jagan
    Naveen, M.
    Chandrasekhar, T.
    Reddy, A. Babul
    Penchalaiah, N.
    Swamy, G. Narayana
    INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 2014, 53 (02): : 208 - 211
  • [40] An efficient synthesis and antimicrobial evaluation of 5-alkenyl- and 5-styryl-1,2,4-oxadiazoles
    Tarasenko, Marina
    Sidneva, Vera
    Belova, Alexandra
    Romanycheva, Anna
    Sharonova, Tatyana
    Baykov, Sergey
    Shetnev, Anton
    Kofanov, Eugeniy
    Kuznetsov, Mikhail A.
    ARKIVOC, 2018, : 458 - 470
12345