Synthesis and evaluation of in vitro antimicrobial activity of novel 2-[2-(aroyl)aroyloxy]methyl-1,3,4-oxadiazoles

被引：0
|
作者：
V. Girish
Noor Fatima Khanum
H. D. Gurupadaswamy
Shaukath Ara Khanum
机构：
[1] University of Mysore,Department of Chemistry
[2] Maharani’s Science College,Department of Food Science and Nutrition
来源：
Russian Journal of Bioorganic Chemistry | 2014年 / 40卷
关键词：
benzophenones; 1,3,4-oxadiazoles; antimicrobial activity; MIC;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Synthetic pathway of the ten novel 2-[2-(aroyl)aroyloxy]methyl-1,3,4-oxadiazoles as new potential antimicrobial agents is illustrated. Intramolecular cyclization of 2-(2-aroylaryloxy) aceto hydrazides to 2-[2-(aroyl)aroyloxy]methyl-1,3,4-oxadiazoles was achieved with triethyl orthoformate in good yields. The compounds were characterized by IR, 1H NMR, mass spectra and by means of CHN analysis. The target compounds were tested for their in vitro antimicrobial activity against representative strains by disc diffusion method and micro dilution methods. Several compounds showed antimicrobial activity comparable with or higher than the standard drugs.
引用
收藏
页码：330 / 335
页数：5
相关论文
共 50 条
  • [1] Synthesis and evaluation of in vitro antimicrobial activity of novel 2-[2-(aroyl)aroyloxy]methyl-1,3,4-oxadiazoles
    Girish, V.
    Khanum, Noor Fatima
    Gurupadaswamy, H. D.
    Khanum, Shaukath Ara
    RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY, 2014, 40 (03) : 330 - 335
  • [2] SYNTHESIS AND CHARACTERIZATION OF NEW 2-(2-THIENYL)-5-ARYL-1,3,4-OXADIAZOLES
    Badiceanu, Carmellina Daniela
    Nuta, Diana Camelia
    Missir, Alexandru-Vasile
    Hrubaru, Madalina
    Limban, Carmen
    FARMACIA, 2018, 66 (03) : 553 - 557
  • [3] SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF PYRAZOLYL 1,3,4-OXADIAZOLES
    Padmavathi, Venkatapuram
    Reddy, Gali Sudhakar
    Reddy, Guda Dinneswara
    Payani, Thalari
    SYNTHETIC COMMUNICATIONS, 2010, 40 (04) : 482 - 493
  • [4] Novel pyrazole integrated 1,3,4-oxadiazoles: Synthesis, characterization and antimicrobial evaluation
    Ningaiah, Srikantamurthy
    Bhadraiah, Umesha K.
    Doddaramappa, Shridevi D.
    Keshavamurthy, Shubakara
    Javarasetty, Chethan
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2014, 24 (01) : 245 - 248
  • [5] Synthesis and antimicrobial studies of a new series of 2-{4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl}-5-substituted-1,3,4-oxadiazoles
    Gaonkar, S. L.
    Rai, K. M. L.
    Prabhuswamy, B.
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2006, 41 (07) : 841 - 846
  • [6] Synthesis, antimicrobial, and anti-inflammatory activities of novel 2-(1-adamantyl)-5-substituted-1,3,4-oxadiazoles and 2-(1-adamantylamino)-5-substituted-1,3,4-thiadiazoles
    Kadi, Adnan A.
    El-Brollosy, Nasser R.
    Al-Deeb, Omar A.
    Habib, Elsayed E.
    Ibrahim, Tarek M.
    El-Emam, Ali A.
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2007, 42 (02) : 235 - 242
  • [7] Synthesis, characterization and anti-bacterial activity of 5-(alkenyl)-2-amino- and 2-(alkenyl)-5-phenyl-1,3,4-oxadiazoles
    Banday, Mudasir R.
    Mattoo, Rayees H.
    Rauf, Abdul
    JOURNAL OF CHEMICAL SCIENCES, 2010, 122 (02) : 177 - 182
  • [8] Synthesis and antimicrobial evaluation of isoxazole-substituted 1,3,4-oxadiazoles
    Marri, Srinivas
    Kakkerla, Ramu
    Krishna, Mudumba Phali Surya Murali
    Rajam, Manchikatla Venkat
    HETEROCYCLIC COMMUNICATIONS, 2018, 24 (05) : 285 - 292
  • [9] Synthesis of Schiff bases of 2-amino-5-aryl-1,3,4-oxadiazoles and their evaluation for antimicrobial activities
    Mishra, P
    Rajak, H
    Mehta, A
    JOURNAL OF GENERAL AND APPLIED MICROBIOLOGY, 2005, 51 (02): : 133 - 141
  • [10] Synthesis and antimicrobial activity of pyrimidinyl 1,3,4-oxadiazoles, 1,3,4-thiadiazoles and 1,2,4-triazoles
    Sekhar, M. Madhu
    Nagarjuna, U.
    Padmavathi, V.
    Padmaja, A.
    Reddy, N. Vasudeva
    Vijaya, T.
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 145 : 1 - 10
12345