Flash nanoprecipitation of hafnia nanoparticle computed tomography contrast agent

被引：0
作者：
Sitong Liu
Matthew Po
Anahita Heshmat
Evan Anguish
Jennifer Andrew
Carlos M Rinaldi-Ramos
机构：
[1] University of Florida,Department of Chemical Engineering
[2] University of Florida,Department of Radiology
[3] University of Florida,Department of Material Science and Engineering
[4] University of Florida,J. Crayton Pruitt Family Department of Biomedical Engineering
来源：
Journal of Nanoparticle Research | 2023年 / 25卷
关键词：
Hafnium oxide; Nanoparticle; Flash nanoprecipitation; Computed tomography; Contrast agents; Medical imaging;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Hafnium oxide (hafnia) nanoparticles have recently attracted attention for their application as computed tomography (CT) contrast agents due to their high X-ray attenuation and low cost. Here we employ flash nanoprecipitation (FNP) to formulate hafnia nanoclusters (HNCs) consisting of a core of precipitated individual hafnia nanoparticles and polylactic acid homopolymer and an outer coating of the block copolymer polylactic acid-b-polyethylene glycol (PLA-b-PEG). The HNCs can be produced with controlled hydrodynamic size in the range of 100–300 nm using a simple 3D-printed FNP mixer. The CT performance of the HNCs was evaluated in a pre-clinical small animal scanner and in a clinical scanner. In both systems the HNCs displayed ~1.5× greater contrast compared to the commercial iodinated molecular contrast agent Omnipaque used clinically.
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  • [21] Mahan MM(2019)Externally triggered heat and drug release from magnetically controlled nanocarriers Int J Pharm 572 118796-71
  • [22] Doiron AL(2015)Single-step assembly of multimodal imaging nanocarriers: MRI and long-wavelength fluorescence imaging Adv Funct Mater 25 4607-361
  • [23] Ostadhossein F(2018)Composite block copolymer stabilized nanoparticles: simultaneous encapsulation of organic actives and inorganic nanostructures J Pharm Sci 107 2465-1306
  • [24] Ostadhossein F(2012)Theranostic nanocarriers combining high drug loading and magnetic particle imaging Nat Methods 9 676-11
  • [25] Bao JF(2017)Facile single-precursor synthesis and surface modification of hafnium oxide nanoparticles for nanocomposite-ray scintillators Methods Mol Biol 1570 47-undefined
  • [26] Nebuloni L(2021)Design of a small-scale multi-inlet vortex mixer for scalable nanoparticle production and application to the encapsulation of biologics by inverse flash nanoprecipitation Nanotheranostics 5 348-undefined
  • [27] Kuhn GA(2017)Fiji: an open-source platform for biological-image analysis Nanoscale 9 1299-undefined
  • [28] Muller R(2016)Magnetic characterization of iron oxide nanoparticles for biomedical applications J Med Phys 41 3-undefined
  • [29] Li YY(undefined)Long circulating tracer tailored for magnetic particle imaging undefined undefined undefined-undefined
  • [30] Hoshyar N(undefined)Evaluation of PEG-coated iron oxide nanoparticles as blood pool tracers for preclinical magnetic particle imaging undefined undefined undefined-undefined
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