The Vitamin C, Thiamine and Steroids in Sepsis (VICTAS) Protocol: a prospective, multi-center, double-blind, adaptive sample size, randomized, placebo-controlled, clinical trial

被引:0
作者
David N. Hager
Michael H. Hooper
Gordon R. Bernard
Laurence W. Busse
E. Wesley Ely
Alpha A. Fowler
David F. Gaieski
Alex Hall
Jeremiah S. Hinson
James C. Jackson
Gabor D. Kelen
Mark Levine
Christopher J. Lindsell
Richard E. Malone
Anna McGlothlin
Richard E. Rothman
Kert Viele
David W. Wright
Jonathan E. Sevransky
Greg S. Martin
机构
[1] Johns Hopkins University,Division of Pulmonary & Critical Care Medicine, Department of Medicine, Johns Hopkins Hospital
[2] Eastern Virginia Medical School and Sentara Healthcare,Division of Pulmonary & Critical Care Medicine, Department of Medicine
[3] Vanderbilt University School of Medicine,Division of Pulmonary & Critical Care Medicine, Department of Medicine
[4] Emory University,Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine
[5] Vanderbilt University Medical Center,Division of Pulmonary & Critical Care, Department of Medicine
[6] Vanderbilt University Medical Center,Critical Illness, Brain Dysfunction, and Survivorship (CIBS) Center
[7] Tennessee Valley Veteran’s Affairs Geriatric Research Education Clinical Center (GRECC),Division of Pulmonary Disease & Critical Care Medicine, Department of Internal Medicine, The VCU Johnson Center for Critical Care and Pulmonary Research
[8] Virginia Commonwealth University School of Medicine,Department of Emergency Medicine, Sidney Kimmel Medical College
[9] Thomas Jefferson University,Department of Emergency Medicine
[10] Emory University,Department of Emergency Medicine
[11] Grady Memorial Hospital,Department of Psychiatry
[12] Johns Hopkins University,Molecular & Clinical Nutrition Section, Intramural Research Program
[13] Vanderbilt University School of Medicine,Department of Biostatistics
[14] National Institute of Diabetes and Digestive and Kidney Diseases,Investigational Drug Service
[15] National Institutes of Health,undefined
[16] Vanderbilt University Medical Center,undefined
[17] Vanderbilt University Medical Center,undefined
[18] Berry Consultants,undefined
[19] LLC,undefined
来源
Trials | / 20卷
关键词
Vitamin C; Thiamine; Hydrocortisone; Sepsis; Septic shock; Mortality; Randomized controlled trial;
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[1]  
Singer M(2016)The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) JAMA 315 801-810
[2]  
Deutschman CS(2003)The epidemiology of sepsis in the United States from 1979 through 2000 N Engl J Med 348 1546-1554
[3]  
Seymour CW(2001)Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care Crit Care Med 29 1303-1310
[4]  
Shankar-Hari M(2017)Incidence and trends of sepsis in US hospitals using clinical vs claims data, 2009-2014 JAMA 318 1241-1249
[5]  
Annane D(2016)The changing epidemiology and definitions of sepsis Clin Chest Med 37 165-179
[6]  
Bauer M(2009)Long-term outcome and quality-adjusted life years after severe sepsis Crit Care Med 37 1268-1274
[7]  
Martin GS(2016)Long-term quality of life among survivors of severe sepsis: analyses of two international trials Crit Care Med 44 1461-1467
[8]  
Mannino DM(2013)Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock, 2012 Intensive Care Med 39 165-228
[9]  
Eaton S(2017)Surviving sepsis campaign: international guidelines for management of sepsis and septic shock: 2016 Intensive Care Med 43 304-377
[10]  
Moss M(2007)Effect of a rapid response system for patients in shock on time to treatment and mortality during 5 years Crit Care Med 35 2568-2575