Characterization and compatibility study of desloratadine

被引：0
作者：
Isabela P. Veronez
Josiane S. P. Daniel
Jerusa S. Garcia
Marcello G. Trevisan
机构：
[1] Institute of Chemistry,LACFar
[2] Federal University of Alfenas (UNIFAL-MG),undefined
[3] National Institute of Science and Technology of Bioanalytical (INCTBio),undefined
[4] State University of Campinas,undefined
来源：
Journal of Thermal Analysis and Calorimetry | 2014年 / 115卷
关键词：
Desloratadine; Compatibility; Thermal analysis; Solid-state characterization;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Desloratadine (DL) is a selective antagonist of the histamine H1 receptor, which has been widely used to treat allergic symptoms, and stands out from other drugs in this therapeutic class because it does not cause sedative effects. In the present study, the physico-chemical properties of DL were fully characterized using six analytical techniques such as Differential Scanning Calorimetry (DSC), Thermogravimetric analysis (TG/DTG), Fourier transform infrared spectroscopy (FT-IR), Raman spectroscopy, Powder X-ray diffraction (PXRD), and scanning electron microscopy (SEM). The DSC curve shows a sharp endothermic event at 158.4 °C, and the TG/DTG curve presents two decomposition events between 178.4 and 451.9 °C. A compatibility study involving DL and nine pharmaceutical excipients generally used in pharmaceutical formulations was performed. Physical binary mixtures of DL with each excipient were prepared in a 1:1 (w/w) ratio. After preparation, the samples were analyzed immediately and the results reveal solid-state interaction with anhydrous lactose, microcrystalline cellulose, magnesium stearate, and stearic acid.
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页码：2407 / 2414
页数：7
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  • [1] Anthes JC(2002)Biochemical characterization of desloratadine, a potent antagonist of the human histamine H1 receptor Eur J Pharm 449 229-237
  • [2] Gilchrest H(2009)Characterization of venlafaxine hydrochloride and compatibility studies with pharmaceutical excipients J Therm Anal Calorim 97 729-733
  • [3] Richard C(2008)Compatibility studies between captopril and pharmaceutical excipients used in tablets formulations J Therm Anal Calorim 91 323-328
  • [4] Eckel S(2000)Drug-excipient interaction and their effect on absorption Pharm Sci Tech 3 336-345
  • [5] Hesk D(1998)Compatibility study between ibuproxam and pharmaceutical excipients using differential scanning calorimetry, hot-stage microscopy and scanning electron microscopy J Pharm Biomed Anal 18 151-163
  • [6] West RE(2011)Compatibility study between ketoprofen and pharmaceutical excipients used in solid dosage forms J Pharm Biomed Anal 56 221-227
  • [7] Williams SM(2010)Compatibility studies of aceclofenac with retard tablet excipients by means of thermal and FT-IR spectroscopic methods J Therm Anal Calorim 104 265-271
  • [8] Greenfeder S(2013)Compatibility of sildenafil citrate and pharmaceutical excipients by thermal analysis and LC–UV J Therm Anal Calorim 111 2037-2044
  • [9] Billah M(2011)Análise térmica aplicada a fármacos e formulações farmacêuticas na indústria farmacêutica Quim Nova 34 1224-1230
  • [10] Kreutner W(2001)Characterization of the solid state: quantitative issues Adv Drug Deliv Rev 48 67-90
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