Serum levels of soluble CD26 and CD30 and their clinical significance in patients with rheumatoid arthritis

被引：0

作者：

Hasan Ulusoy

Ayhan Kamanli

Necip Ilhan

Omer Kuru

Sule Arslan

Gokhan Alkan

Salih Ozgocmen

机构：

[1] Firat University,Division of Rheumatology, Department of Physical Medicine and Rehabilitation

[2] Faculty of Medicine,Department of Biochemistry

[3] Firat University,Division of Rheumatology, Department of Physical Medicine and Rehabilitation

[4] Faculty of Medicine, Department of Physical Medicine and Rehabilitation

[5] Ondokuz Mayis University,Division of Rheumatology, Department of Physical Medicine and Rehabilitation

[6] Faculty of Medicine,undefined

[7] Gaziosmanpasa University,undefined

[8] Faculty of Medicine,undefined

[9] Erciyes University,undefined

[10] School of Medicine,undefined

[11] Gevher Nesibe Hospital,undefined

来源：

Rheumatology International | 2012年 / 32卷

关键词：

Rheumatoid arthritis; Disease activity; CD26; CD30;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

The aim of this study was to assess serum levels and clinical significance of soluble CD26 (sCD26) and soluble CD30 (sCD30) in patients with rheumatoid arthritis (RA). Forty-eight patients with RA and 30 healthy controls were enrolled. Serum sCD26 and sCD30 levels were measured using ELISA. Serum sCD26 levels were significantly lower (P = 0.011), whereas sCD30 levels were higher (P = 0.008) in patients with RA than controls. Serum levels of sCD30 correlated significantly with clinical and laboratory parameters of disease activity like erythrocyte sedimentation rate, C-reactive protein, disease activity scores-28 and health assessment questionnaire score; however, sCD26 levels did not correlate any of these activity parameters. These results suggest that serum sCD30 levels increased and correlated significantly with disease activity, indicating a novel follow-up parameter in RA. Serum levels of sCD26 may be lessen but not related to disease activity in RA.

引用

页码：3857 / 3862

页数：5