Sphingosine kinase 2: a controversial role in arthritis

被引：0
|
作者：
Tao Xu
Lin Li
Cheng Huang
Yunyun Peng
Jun Li
机构：
[1] Anhui Medical University,School of Pharmacy, Anhui Key Laboratory of Bioactivity of Natural Products
[2] Anhui Medical University,Institute for Liver Diseases of Anhui Medical University (AMU)
来源：
Rheumatology International | 2014年 / 34卷
关键词：
Inflammatory Arthritis; Sphingosine; Synovial Fibroblast; Sphingosine Kinase; Suppress Cell Proliferation;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
SphK2 is a nuclear protein that suppresses cell proliferation by inhibiting DNA synthesis, while also enhancing apoptosis in diverse cell types. ABC294640 (a selectively SphK2 inhibitor) attenuated the knee joint histological damage and pain associated with MIA-induced OA in rats. However, recent studies revealed that genetic inhibition of SphK2 did not significantly impact the severity or progression of inflammatory arthritis, while pharmacologic inhibition of SphK2 led to significantly more severe arthritis. Therefore, SphK2 plays a controversial role in arthritis.
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页码：1015 / 1016
页数：1
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