Noninvasive Ventilation for Preterm Twin Neonates with Respiratory Distress Syndrome: A Randomized Controlled Trial

被引：0
作者：
Long Chen
Li Wang
Jie Li
Nan Wang
Yuan Shi
机构：
[1] Daping Hospital,Department of Pediatrics
[2] Research Institute of Surgery,Department of Obstetrics and Gynecology
[3] Third Military Medical University,undefined
[4] The First Affiliated Hospital of Chongqing Medical University,undefined
来源：
Scientific Reports | / 5卷
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摘要：
Noninvasive ventilation has been proven to be effective strategies for reducing the need for endotracheal ventilation in preterm infant with respiratory distress syndrome (RDS), however the best option needs to be further determined. A single center, paired design, randomized, controlled trial was conducted between Jan 2011 and July 2014. Preterm twins with RDS were included. One of a pair was randomized to NIPPV, while another to NCPAP. Surfactant was administrated as rescue treatment. The primary outcome was the need for endotracheal ventilation. The secondary outcomes were the complications. 143 pairs were randomized and 129 pairs finished the trial. The rates of endotracheal ventilation did not differ significantly between NIPPV and NCPAP groups (11.9% vs 19.6%, P = 0.080). This difference was not observed in the subgroup of infants who received surfactant therapy (11.1% vs 19.7%, P = 0.087). No secondary outcomes also differed significantly between the two groups. NIPPV did not result in a significantly lower incidence of intubation as compared with NCPAP in preterm twins with RDS.
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[1]  
Caryn SC(2008)The probability of neonatal respiratory distress syndrome as a function of gestational age and lecithin/sphingomyelin ratio Am J Perinatol 25 473-480
[2]  
Stoll BJ(2010)Neonatal outcomes of extremely preterm infants from the NICHD Neonatal Research Network Pediatrics 126 443-456
[3]  
Schmidt B(2010)Impact of bronchopulmonary dysplasia, brain injury and severe retinopathy on the outcome of extremely low-birthweight infants at 18 months: results from the Trial of Indomethacin Prophylaxis in Preterms JAMA. 289 1124-1129
[4]  
Stroustrup A(2010)Epidemiological characteristics and resource use in neonates with bronchopulmonary dysplasia: 1993–2006 Pediatrics 126 291-297
[5]  
Trasande L(2014)Post-Newborn: A New Concept of Period in Early Life. Frontier and Future Development of Information Technology in Medicine and Education LNEE. 269 1343-1350
[6]  
Long C(2003)A randomized, controlled trial comparing two different continuous positive airway pressure systems for the successful extubation of extremely low birth weight infants Pediatrics 112 1031-1038
[7]  
Jie L(2008)Noninvasive ventilation of the preterm infant Early Hum Dev 84 815-819
[8]  
Nan W(2009)Non-invasive respiratory support of preterm neonates with respiratory distress: continuous positive pressure and nasal intermittent positive ventilation Seminars Fetal Neonatal Med 14 14-20
[9]  
Yuan S(2008)Gas exchange and lung inflammation using nasal intermittent positive-pressure ventilation versus synchronized intermittent mandatory ventilation in piglets with saline lavage-induced lung injury: an observational study Crit Care Med 36 183-187
[10]  
Stefanescu BM(2010)Nasal intermittent positive pressure ventilation in the newborn: review of literature and evidence-based guidelines J Perinatol 30 505-512
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