Expression of bcl-2 in Autoimmune and Helicobacter pylori-Associated Atrophic Gastritis

被引:0
作者
Y. Maor-Kendler
G. Gabay
J. Bernheim
T. Naftali
I. Lesin
G. Leichtman
I. Pomeranz
B. Novis
机构
来源
Digestive Diseases and Sciences | 1999年 / 44卷
关键词
ATROPHIC GASTRITIS; HELICOBACTER PYLORI; AUTOIMMUNE GASTRITIS;
D O I
暂无
中图分类号
学科分类号
摘要
Chronic atrophic gastritis can be induced eitherby H. pylori or by an autoimmune process. The proteinproduct of bcl-2, which is a protooncogene, blocksapoptosis. Aberrant bcl-2 expression has been found in 68% of atrophic gastritis patients. The aimof this study was to compare bcl-2 expression in 20autoimmune atrophic gastritis patients to that in 20 H.pylori-associated atrophic gastritis patients. Twenty patients with H. pylori antral gastritisbut without atrophy served as controls. The bcl-2expression was assessed by immunohistochemical stainingof gastric biopsies, using mouse anti-human bcl-2 monoclonal antibodies. Autoimmune atrophicgastritis patients were younger, mainly females, with asignificantly higher serum gastrin level than the H.pylori-associated atrophic gastritis group (P < 0.001). The bcl-2 was expressed in 10/20 (50%)of autoimmune atrophic gastritis patients, in 9/20 (45%)of H. pylori-associated atrophic gastritis patients (P= 0.73), and in 2/20 (10%) of controls. There was no correlation between bcl-2expression and the presence of intestinal metaplasia (P= 0.35). Our findings confirm that H. pylori-associatedatrophic gastritis and autoimmune atrophic gastritis are two different conditions, but with equalexpression of bcl-2. Excessive expression of bcl-2 isfound only in atrophic gastritis, but not in H. pyloriantral gastritis without atrophy.
引用
收藏
页码:680 / 685
页数:5
相关论文
共 89 条
[1]  
Kuipers EJ(1997)Role of Scand J Gastroenterol 32 28-34
[2]  
Klinkenberg-Knol EC(1997) in the pathogenesis of atrophic gastritis N Engl J Med 337 1441-1448
[3]  
Vandenbroucke-Grauls CMJE(1991)Pernicious anemia BMJ 302 1302-1305
[4]  
Appelmelk BJ(1991)Association between infection with N Engl J Med 325 1127-1131
[5]  
Schenk BE(1991) and risk of gastric cancer: Evidencefrom a prospective investigation N Engl J Med 325 1132-1136
[6]  
Meuwissen SGM(1994) infection and therisk of gastric carcinoma Lancet 343 243-244
[7]  
Toh B-H(1995) infection and gastric carcinoma among Japanese Americans in Hawaii Am J Pathol 146 20-26
[8]  
Van Driel IR(1994) and gastric cancer Cancer 73 2900-2904
[9]  
Gleeson PA(1995)The Cancer 75 2209-2213
[10]  
Forman D(1996) protooncogene and the gastrointestinal epithelial tumor progression model Am J Pathol 149 1449-1457