Synthesis and antimycobacterial activities of some new N-acylhydrazone and thiosemicarbazide derivatives of 6-methyl-4,5-dihydropyridazin-3(2H)-one

被引：0
作者：
Oya Unsal Tan
Keriman Ozadali
Perumal Yogeeswari
Dharmarajan Sriram
Ayla Balkan
机构：
[1] University of Hacettepe,Department of Pharmaceutical Chemistry, Faculty of Pharmacy
[2] Birla Institute of Technology & Science – Pilani,Medicinal Chemistry & Antimycobacterial Research Laboratory, Pharmacy Group
[3] Hyderabad Campus,undefined
来源：
Medicinal Chemistry Research | 2012年 / 21卷
关键词：
Antimycobacterial activity; 6-Methyl-4,5-dihydropyridazin-3(2H)-one; Acylhydrazone; Thiosemicarbazide;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
In this study, twenty-five new 6-methyl-4,5-dihydropyridazin-3(2H)-one derivatives having N-acylhydrazone and thiosemicarbazide moieties were synthesized. The target compounds were tested for their antimycobacterial activity in vitro against Mycobacterium tuberculosis H37Rv using the agar dilution method. Among the synthesized compounds, N′-(2,4-dichlorobenzylidene)-2-(3-methyl-6-oxo-5,6-dihydropyridazin-1(4H)-yl)acetohydrazide 4g was found to be the most active compound with minimum inhibitory concentration of 0.78 μM and was more potent than ethambutol and ciprofloxacin.
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页码：2388 / 2394
页数：6
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