A phase I/II study of adoptive immunotherapy using donor liver graft-derived natural killer cells to prevent bloodstream infection after liver transplantation: a study protocol

被引:0
作者
Masahiro Ohira
Yuki Imaoka
Koki Sato
Koki Imaoka
Ryosuke Nakano
Naoki Tanimine
Hiroyuki Tahara
Kentaro Ide
Tsuyoshi Kobayashi
Yuka Tanaka
Hideki Ohdan
机构
[1] Hiroshima University,Department of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences
[2] Hiroshima University Hospital,Medical Center for Translational and Clinical Research
关键词
Immunotherapy; NK cell; Liver transplantation; Bloodstream infection;
D O I
10.1186/s41231-022-00126-4
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 100 条
  • [1] Baganate F(2018)Early mortality after liver transplantation: Defining the course and the cause Surgery 164 694-704
  • [2] Beal EW(2016)Epidemiology of Bloodstream Infections in a Multicenter Retrospective Cohort of Liver Transplant Recipients Transplantation direct 2 e67-85
  • [3] Tumin D(2020)Risk stratification for early bacteremia after living donor liver transplantation: a retrospective observational cohort study BMC Surg 20 2-95
  • [4] Azoulay D(2010)Posttransplant bacteremia in adult living donor liver transplant recipients Liver Transpl 16 1379-10
  • [5] Mumtaz K(2012)Bacterial sepsis after living donor liver transplantation: the impact of early enteral nutrition J Am Coll Surg 214 288-72
  • [6] Black SM(2008)Functions of natural killer cells Nat Immunol 9 503-9
  • [7] Santos CA(2006)Difference in cytotoxicity against hepatocellular carcinoma between liver and periphery natural killer cells in humans Hepatology 43 362-99
  • [8] Hotchkiss RS(2006)Adoptive transfer of TRAIL-expressing natural killer cells prevents recurrence of hepatocellular carcinoma after partial hepatectomy Transplantation 82 1712-35
  • [9] Chapman WC(2022)Pilot study to determine the safety and feasibility of deceased donor liver natural killer cell infusion to liver transplant recipients with hepatocellular carcinoma Cancer Immunol Immunother 71 589-80
  • [10] Olsen MA(2009)Adoptive immunotherapy with liver allograft-derived lymphocytes induces anti-HCV activity after liver transplantation in humans and humanized mice J Clin Invest 119 3226-33