What is the normal value of the neutrophil-to-lymphocyte ratio?

被引：513
作者：
Forget P. [1 ,4 ]
Khalifa C. [1 ]
Defour J.-P. [2 ]
Latinne D. [2 ]
Van Pel M.-C. [3 ]
De Kock M. [1 ]
机构：
[1] Department of Anesthesiology, Cliniques Universitaires Saint-Luc, Institute of Neuroscience (pole CEMO), Université Catholique de Louvain, Brussels
[2] Department of Clinical Biology, Cliniques Universitaires Saint-Luc, Brussels
[3] CESI-Prévention et Protection ASBL, Brussels
[4] Department of Anesthesiology and Perioperative Medicine, Vrije Universiteit Brussel (VUB), Universitair Ziekenhuis Brussel (UZ Brussel), Laarbeeklaan, 101, Brussels
来源：
BMC Research Notes | / 10卷 / 1期
关键词：
Cells count; Laboratory testing; Neutrophil-to-lymphocyte ratio; Reference values;
D O I：
10.1186/s13104-016-2335-5
中图分类号：
学科分类号：
摘要：
Background: Neutrophil-to-lymphocyte ratio (NLR) has proven its prognostic value in cardiovascular diseases, infections, inflammatory diseases and in several types of cancers. However, no cut-off has been proposed on the basis of reference values coming from healthy population. Methods: Routine blood samples were obtained (n = 413) from workers (age: median 38, range: 21-66 years) involved in a health care prevention program, to determine means, standard deviations (SDs), 95% confidence intervals (95% CI), percentiles P2.5 and P97.5. A second independent sample of healthy volunteers is compared (n = 29). Results: The mean NLR is 1.65 [±1.96 SD: 0.78-3.53] (95% CI [0.75-0.81] and [3.40-3.66]). In the second cohort (healthy control), the NLR values are in the same range, whichever the used analyzer. No NLR assessed in the validation series is out of the proposed limits. Conclusions: We have identified that the normal NLR values in an adult, non-geriatric, population in good health are between 0.78 and 3.53. These data will help to define the normal values of the NLR. © 2017 The Author(s).
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页数：3
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