Phase II trial of sequential paclitaxel and 1 h infusion of bryostatin-1 in patients with advanced esophageal cancer

被引:0
作者
Geoffrey Y. Ku
David H. Ilson
Lawrence H. Schwartz
Marinela Capanu
Eileen O’Reilly
Manish A. Shah
David P. Kelsen
Gary K. Schwartz
机构
[1] Memorial Sloan-Kettering Cancer Center,Department of Medicine
[2] Memorial Sloan-Kettering Cancer Center,Department of Radiology
[3] Memorial Sloan-Kettering Cancer Center,Department of Biostatistics and Epidemiology
来源
Cancer Chemotherapy and Pharmacology | 2008年 / 62卷
关键词
Bryostatin-1; Esophageal cancer; Gastroesophageal cancer; Paclitaxel; Protein kinase C;
D O I
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学科分类号
摘要
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页码:875 / 880
页数:5
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[1]  
Ajani JA(2006)A multi-center phase II study of sequential paclitaxel and bryostatin-1 (NSC 339555) in patients with untreated, advanced gastric or gastroesophageal junction adenocarcinoma Invest New Drugs 24 353-357
[2]  
Jiang Y(1995)Inhibition of leukemic cell growth by the protein kinase C activator bryostatin 1 correlates with the dephosphorylation of cyclin-dependent kinase 2 Cancer Res 55 3716-3720
[3]  
Faust J(2003)Esophageal cancer N Engl J Med 349 2241-2252
[4]  
Chang BB(1993)Effects of cisplatin on the induction of apoptosis in proliferating hepatoma cells and nonproliferating immature thymocytes Cancer Res 53 2133-2139
[5]  
Ho L(1992)Potentiation of the activity of 1–beta- Cancer Res 52 6270-6278
[6]  
Yao JC(1994)-arabinofuranosylcytosine by the protein kinase C activator bryostatin 1 in HL–60 cells: association with enhanced fragmentation of mature DNA J Exp Med 180 525-535
[7]  
Rousey S(1987)Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis Carcinogenesis 8 1343-1346
[8]  
Dakhil S(1995)Bryostatin 1, an activator of protein kinase C, inhibits tumor promotion by phorbol esters in SENCAR mouse skin Br J Cancer 72 998-1003
[9]  
Cherny RC(2007)Bryostatin 1, a novel antineoplastic agent and protein kinase C activator, induces human myalgia and muscle metabolic defects: a 31P magnetic resonance spectroscopic study Ann Oncol 18 898-902
[10]  
Craig C(1994)Paclitaxel given by a weekly 1-h infusion in advanced esophageal cancer J Biol Chem 269 31685-31692