Age-related thymic involution in C57BL/6J × DBA/2J recombinant-inbred mice maps to mouse chromosomes 9 and 10

被引：0
作者：
H-C Hsu
H-G Zhang
L Li
N Yi
P-A Yang
Q Wu
J Zhou
S Sun
X Xu
X Yang
L Lu
G Van Zant
R W Williams
D B Allison
J D Mountz
机构：
[1] The University of Alabama at Birmingham,Department of Medicine, Division of Clinical Immunology and Rheumatology
[2] Veterans Administration Medical Center,Department of Biostatistics
[3] Section of Statistical Genetics,Center for Neuroscience and Department of Anatomy and Neurobiology
[4] The University of Alabama at Birmingham,Division of Hematology/Oncology
[5] University of Tennessee,undefined
[6] The Markey Cancer Center,undefined
[7] The University of Kentucky Medical Center,undefined
来源：
Genes & Immunity | 2003年 / 4卷
关键词：
thymic involution; negative exponential curve; genetic linkage; recombinant inbred mice; QTL;
D O I：
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中图分类号：
学科分类号：
摘要：
A comprehensive analysis of initial thymus size and involution rate has not been quantitated for different genetic backgrounds of mice, thus genetic linkage analysis of thymic involution has not been possible. Here, we have used a mathematical method to analyze the age-related decline in thymocyte count in C57BL/6 and DBA/2 mice and have observed that thymic involution could be best fit with a negative exponential curve N(t)=β0 × exp(−β1t), where t represents the age (day). This regression model was applied to C57BL/6 × DBA/2 (B × D) recombinant inbred strains of mice to identify the genetic loci influencing age-related thymic involution. There was a dramatic genetic effect of B and D alleles on thymocyte count at young age and the age-related thymic involution rate. The strongest quantitative trait loci (QTL) influencing the rate of thymic involution were mapped to mouse chromosome (Chr) 9 (D9Mit20 at 62 cM) and Chr 10 (D10Mit61 at 32 cM). The strongest QTLs influencing the initial thymocyte count were mapped to ChrX (DXMit324 at 26.5 cM) and Chr 3 (D3Mit127 at 70.3 cM). The present study suggests that the initial thymus size and the rate of thymic involution may be influenced by a relatively small number of genetic loci.
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页码：402 / 410
页数：8
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共 143 条
  • [1] Boyd E(1932)The weight of the thymus gland in health and disease Am J Dis Child 43 1162-1214
  • [2] Aspinall R(2000)Thymic involution in aging J Clin Immunol 20 250-256
  • [3] Andrew D(1998)Insulin growth factor-I inhibits apoptosis in hematopoietic progenitor cells. Implications in thymic aging Ann NY Acad Sci 840 518-524
  • [4] Kelley KW(1996)Impaired survival and proliferation in IL-7 receptor-deficient peripheral T cells J Immunol 157 5315-5323
  • [5] Meier WA(1995)Prevention of age-related T cell apoptosis defect in CD2-fas-transgenic mice J Exp Med 182 129-137
  • [6] Minshall C(1999)Proliferation, apoptosis and thymic involution Tissue Cell 31 391-396
  • [7] Maraskovsky E(1985)The involution of the ageing human thymic epithelium is independent of puberty. A morphometric study Scand J Immunol 22 563-575
  • [8] Teepe M(1982)Involution patterns of the human thymus. I Size of the cortical area as a function of age Clin Exp Immunol 47 497-504
  • [9] Morrissey PJ(2002)Age-related change in thymic T-cell development is associated with genetic loci on mouse chromosomes 1, 3, and 11 Mech Ageing Dev 123 1145-1158
  • [10] Zhou T(1968)Absence of thymus in a mouse mutant Nature 217 370-371
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