The determinants of bone mineral density in Chinese men—results from Mr. Os (Hong Kong), the first cohort study on osteoporosis in Asian men

被引:0
作者
E. M. C. Lau
P. C. Leung
T. Kwok
J. Woo
H. Lynn
E. Orwoll
S. Cummings
J. Cauley
机构
[1] Hong Kong Orthopaedic and Osteoporosis Center for Treatment and Research,Department of Orthopedics and Traumatology
[2] The Chinese University of Hong Kong,Department of Medicine and Therapeutics
[3] The Chinese University of Hong Kong,School of Public Health
[4] The Chinese University of Hong Kong,Department of Endocrinology and Metabolism
[5] Oregon Health Sciences University,Department of Medicine
[6] University of California,Department of Epidemiology
[7] University of Pittsburgh,undefined
来源
Osteoporosis International | 2006年 / 17卷
关键词
Asian men; Cigarette smoking; Corticosteroid; Medical factors; Osteoporosis;
D O I
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中图分类号
学科分类号
摘要
Mr. Os (Hong Kong) is the first study to address the risk factors for osteoporosis in Asian men. A standardized, structured interview and dual X-ray densitometry (DEXA) were performed on 2,000 Chinese men aged 65–92. By multiple regression, the following factors were found to be positively associated with BMD at both the total hip and the spine: body weight, grip strength and a history of diabetes mellitus. The following factors were found to be negatively associated with BMD at both the total hip and spine: cigarette smoking, a history of gastrectomy or bowel resection, current use of inhaled steroid and a history of fracture after 50 years. Moreover, a history of chronic obstructive pulmonary disease (COPD) was negatively associated with BMD at the total hip, and age, the use of an alpha-blocker, thiazide diuretic and nitrate were associated with a higher BMD at the spine. A total of 21.8% of the variance in total hip and 31.5% of the variance in total spine BMD was accounted for in the multivariate analysis.
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页码:297 / 303
页数:6
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